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- W1546831061 abstract "Cross-over experiments performed in dogs showed that Doxapram hydrochloride in a single-dose injection was as effective asd- amphetamine in shortening the recovery time from a standardized dose of thiopental anaesthesia and was more effective than methylphemdate in the dosages that were compared No untoward effects were observed in any of these experiments When Doxapram hydrochloride was used m an intravenous infusion method for 50 healthy female patients following an elective dilatation and curettage of the uterus, the drug was effective for stimulating respirations (both tidal volume and respiration rate) without producing any appreciable circulatory changes In four instances, there were signs of central nervous system irritation which subsided promptly upon discontinuation of the Doxapram infusion An appreciable difference in the lime for full recovery to occur was found between patients receiving the analeptic and others who did not Direct clinical observation leaves no doubt that an arousal effect is produced which persists along with the augmented breathing response However, an accelerated recovery from thiopental anaesthesia is not a prominent effect with respect to the expected recovery time because it did not appreciably reduce the total “sleeping time” following a double “sleep dose” of thiopental in humans" @default.
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- W1546831061 date "1965-05-01" @default.
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- W1546831061 title "Influence of doxapram hydrochloride on recovery from Thiopental anaesthesia" @default.
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- W1546831061 doi "https://doi.org/10.1007/bf03004143" @default.
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