Matches in SemOpenAlex for { <https://semopenalex.org/work/W1546896073> ?p ?o ?g. }
- W1546896073 endingPage "292" @default.
- W1546896073 startingPage "282" @default.
- W1546896073 abstract "Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection. However, most multicellular organisms have postmitotic tissues, with limited opportunity for selective removal of cells harboring persistent damage and deleterious mutations, which can therefore contribute to functional decline, disease, and death. Key in this process is the role of genome maintenance, the network of protein products that repair DNA damage and signal DNA damage response pathways. Genome maintenance is beneficial early in life by swiftly eliminating DNA damage or damaged cells, facilitating rapid cell proliferation. However, at later ages accumulation of unrepaired damage and mutations, as well as ongoing cell depletion, promotes cancer, atrophy, and other deleterious effects associated with aging. As such, genome maintenance and its phenotypic sequelae provide yet another example of antagonistic pleiotropy in aging and longevity." @default.
- W1546896073 created "2016-06-24" @default.
- W1546896073 creator A5012398734 @default.
- W1546896073 date "2014-01-25" @default.
- W1546896073 modified "2023-09-23" @default.
- W1546896073 title "Aging genomes: A necessary evil in the logic of life" @default.
- W1546896073 cites W130725917 @default.
- W1546896073 cites W1485571925 @default.
- W1546896073 cites W1497143641 @default.
- W1546896073 cites W1509538618 @default.
- W1546896073 cites W1964013868 @default.
- W1546896073 cites W1964444099 @default.
- W1546896073 cites W1965004314 @default.
- W1546896073 cites W1968220216 @default.
- W1546896073 cites W1970356965 @default.
- W1546896073 cites W1971018769 @default.
- W1546896073 cites W1972720762 @default.
- W1546896073 cites W1973677817 @default.
- W1546896073 cites W1973723400 @default.
- W1546896073 cites W1974015196 @default.
- W1546896073 cites W1974518541 @default.
- W1546896073 cites W1976856900 @default.
- W1546896073 cites W1980523428 @default.
- W1546896073 cites W1981148605 @default.
- W1546896073 cites W1982602899 @default.
- W1546896073 cites W1983518138 @default.
- W1546896073 cites W1984318436 @default.
- W1546896073 cites W1984756334 @default.
- W1546896073 cites W1987297410 @default.
- W1546896073 cites W1987523847 @default.
- W1546896073 cites W1989880074 @default.
- W1546896073 cites W1990484467 @default.
- W1546896073 cites W1990711772 @default.
- W1546896073 cites W2001188663 @default.
- W1546896073 cites W2001258296 @default.
- W1546896073 cites W2001595307 @default.
- W1546896073 cites W2002358384 @default.
- W1546896073 cites W2004778468 @default.
- W1546896073 cites W2004808899 @default.
- W1546896073 cites W2008757142 @default.
- W1546896073 cites W2009720434 @default.
- W1546896073 cites W2010455776 @default.
- W1546896073 cites W2012753533 @default.
- W1546896073 cites W2013326913 @default.
- W1546896073 cites W2016507261 @default.
- W1546896073 cites W2020331089 @default.
- W1546896073 cites W2023990700 @default.
- W1546896073 cites W2026711486 @default.
- W1546896073 cites W2027574957 @default.
- W1546896073 cites W2029014149 @default.
- W1546896073 cites W2030297710 @default.
- W1546896073 cites W2037846776 @default.
- W1546896073 cites W2040342712 @default.
- W1546896073 cites W2041198010 @default.
- W1546896073 cites W2042436857 @default.
- W1546896073 cites W2044287438 @default.
- W1546896073 cites W2048614750 @default.
- W1546896073 cites W2049805294 @default.
- W1546896073 cites W2051279310 @default.
- W1546896073 cites W2055071743 @default.
- W1546896073 cites W2055471929 @default.
- W1546896073 cites W2056924563 @default.
- W1546896073 cites W2058484936 @default.
- W1546896073 cites W2059766488 @default.
- W1546896073 cites W2060350590 @default.
- W1546896073 cites W2063770747 @default.
- W1546896073 cites W2065890382 @default.
- W1546896073 cites W2067264255 @default.
- W1546896073 cites W2067666985 @default.
- W1546896073 cites W2068403109 @default.
- W1546896073 cites W2069119604 @default.
- W1546896073 cites W2069519394 @default.
- W1546896073 cites W2071482060 @default.
- W1546896073 cites W2073582763 @default.
- W1546896073 cites W2073955086 @default.
- W1546896073 cites W2074510500 @default.
- W1546896073 cites W2077496230 @default.
- W1546896073 cites W2081617336 @default.
- W1546896073 cites W2085382072 @default.
- W1546896073 cites W2086289230 @default.
- W1546896073 cites W2086535578 @default.
- W1546896073 cites W2091060354 @default.
- W1546896073 cites W2096136751 @default.
- W1546896073 cites W2096587251 @default.
- W1546896073 cites W2096791516 @default.
- W1546896073 cites W2096846805 @default.
- W1546896073 cites W2106663689 @default.
- W1546896073 cites W2112444085 @default.
- W1546896073 cites W2116054786 @default.
- W1546896073 cites W2117178083 @default.
- W1546896073 cites W2119742125 @default.
- W1546896073 cites W2121672398 @default.
- W1546896073 cites W2123336312 @default.
- W1546896073 cites W2123490990 @default.
- W1546896073 cites W2124020069 @default.
- W1546896073 cites W2124037827 @default.
- W1546896073 cites W2125489655 @default.
- W1546896073 cites W2126602684 @default.