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- W1546983597 abstract "The process of cell differentiation in Friend‐erythroleukemia cells was accompanied by 80–90% inhibition of p53 synthesis. This decrease was found to be linked to changes in cell‐cycle distribution characteristics of the growth arrest program during differentiation rather than to the induction of the globin genes. The shut‐off in the expression of p53 always preceded the specific arrest of cells in the G 0 /G 1 phase. Interferon did not modulate down the expression of p53 if added to transformed non‐induced Friend‐erythroleukemia cells; however, it slightly enhanced the extent of reduction in p53 synthesis if added during cell differentiation, thus suggesting a differential effect of interferon between cells at different stages of differentiation" @default.
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- W1546983597 date "1983-10-17" @default.
- W1546983597 modified "2023-10-14" @default.
- W1546983597 title "Reduction in p53 synthesis during differentiation of Friend-erythroleukemia cells" @default.
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- W1546983597 doi "https://doi.org/10.1016/0014-5793(83)80792-3" @default.
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