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- W1547090225 abstract "Sestrin2 is a stress-inducible protein that functions as an antioxidant and inhibitor of mTOR complex 1. In a recent study, we found that Sestrin2 overexpression in brown adipocytes interfered with normal metabolism by reducing mitochondrial respiration through the suppression of uncoupling protein 1 (UCP1) expression. The metabolic effects of Sestrin2 in brown adipocytes were dependent on its antioxidant activity, and chemical antioxidants produced similar effects in inhibiting UCP1-dependent thermogenesis. These observations suggest that low levels of ROS in brown adipocytes can actually be beneficial and necessary for proper metabolic homeostasis. In addition, considering that Sestrins are ROS-inducible and perform ROS-detoxifying as well as other metabolism-controlling functions, they are potential regulators of mitohormesis. This is a concept in which overall beneficial effects result from low-level oxidative stress stimuli, such as the ones induced by caloric restriction or physical exercise. In this perspective, we incorporate our recent insight obtained from the Sestrin2 study towards a better understanding of the relationship between ROS, Sestrin2 and mitochondrial metabolism in the context of brown adipocyte physiology." @default.
- W1547090225 created "2016-06-24" @default.
- W1547090225 creator A5020815556 @default.
- W1547090225 creator A5028501878 @default.
- W1547090225 creator A5048925751 @default.
- W1547090225 creator A5068682787 @default.
- W1547090225 creator A5072547453 @default.
- W1547090225 date "2015-07-24" @default.
- W1547090225 modified "2023-10-18" @default.
- W1547090225 title "Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue" @default.
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