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- W1547149646 abstract "Rat kidney mitochondria, in the presence of ATP, Pi, and magnesium ions, converted pyruvate and bicarbonate to malate, fumarate, and citrate and, in the presence of glutamate, also to aspartate. The addition of fluorocitrate strongly inhibited pyruvate utilization and 14CO2 incorporation into organic acids. The inhibition of 14CO2 incorporation into organic acids in the presence of fluorocitrate appeared to be caused by malonyl coenzyme A produced by fluorocitrate stimulation of acetyl-CoA carboxylase. This inhibition by fluorocitrate of 14CO2 incorporation was reversed by carnitine, acetylcarnitine, acylcarnitines, isocitrate, α-ketoglutarate, succinate, fumarate, and glutamate, but not by citrate, β-hydroxybutyrate, or caprylate. The ratio of carnitine to fluorocitrate determined the degree of reversal of this inhibition. The reversal of inhibition by carnitine or acylcarnitine resulted in greatly increased citrate formation, with nearly all of the 14CO2 being incorporated into citrate, and in nearly complete inhibition of malate synthesis. Fluorocitrate inhibited oxidation of citrate. In the presence of tricarboxylic cycle intermediates, the incorporation of bicarbonate-14C into malate was greatly increased. With fluorocitrate in the system, the incorporation of radioactive bicarbonate into malate in the presence of α-ketoglutarate and succinate did not change, but decreased in the presence of fumarate." @default.
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- W1547149646 date "1968-04-01" @default.
- W1547149646 modified "2023-09-28" @default.
- W1547149646 title "Inhibition of Pyruvate Carboxylation by Fluorocitrate in Rat Kidney Mitochondria" @default.
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- W1547149646 doi "https://doi.org/10.1016/s0021-9258(18)93528-3" @default.
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