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- W1547252381 abstract "Publisher Summary This chapter discusses the eicosanoid metabolism and bioactivation by microsomal cytochrome P450. Microsomal cytochrome P450 participates in the metabolic transformation of several eicosanoids by catalyzing both, nicotinamide adenine dinucleotide phosphate (NADPH)-independent and NADPH-dependent reactions. This distinction reflects the marked differences in types of oxygen chemistry involved in these reactions—that is, the NADPH dependent activation of atmospheric oxygen or the NADPH-independent isomerization of arachidonic acid hydroperoxides. Microsomal P450 oxidizes a variety of eicosanoids that, in addition to arachidonic acid, includes prostanoids and leukotrienes. For the most part, these reactions result in the hydroxylation of the eicosanoid ultimate or penultimate carbon atoms. While it has been generally accepted that these reactions result in an attenuation of the biological activities of their substrates and that they may be important in eicosanoid catabolism, recent studies have indicated that some ω/ω-1 oxidized prostanoids have shown unique and potent biological properties." @default.
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- W1547252381 date "1996-01-01" @default.
- W1547252381 modified "2023-09-22" @default.
- W1547252381 title "Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450" @default.
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- W1547252381 doi "https://doi.org/10.1016/s1569-2558(08)60348-3" @default.
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