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• W1547391041 abstract "Case Reports1 February 1956OBSERVATIONS ON A CASE OF MIXED PORPHYRIA WITH SPECIAL REFERENCE TO PATHOGENESIS AND TREATMENTALBERT L. FREEDMAN, M.D.ALBERT L. FREEDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-391 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has recently been possible to study a young man with diabetes mellitus and mixed porphyria. This paper deals with observations concerning the clinical course, pathogenesis and therapeutics in the latter disease. The association of diabetes with porphyria has occasionally been noted1 and seems most common in porphyria cutanea tarda,2, 3 but so far as we are aware has not been previously described in mixed porphyria.A brief review of the types and major features of porphyria, following Watson's classification, is helpful in any discussion of this disease and is presented in table 1.Because of its unusual features our...Bibliography1. SterlingSilverRicketts KMHT: Development of porphyria in diabetes mellitus; report of three cases, Arch. Int. Med. 84: 965, 1949. CrossrefGoogle Scholar2. SchmidSchwartzWatson RSCJ: Porphyrin content of bone marrow and liver in the various forms of porphyria, Arch. Int. Med. 93: 167, 1954. CrossrefGoogle Scholar3. BrunstingMasonAldrich LAHLRA: Adult form of chronic porphyria with cutaneous manifestations; report of 17 additional cases, J. A. M. A. 146: 1207, 1951. CrossrefMedlineGoogle Scholar4. Watson CJ: Porphyrin metabolism, in Diseases of metabolism, Duncan, G. G., Editor, 3d Ed., 1952, W. B. Saunders Co., Philadelphia, p. 1079. Google Scholar5. WatsonSchwartz CJS: A simple test for urinary porphobilinogen, Proc. Soc. Exper. Biol. and Med. 47: 393, 1941. CrossrefGoogle Scholar6. Schwartz S: Clinical aspects of porphyrin metabolism, Veterans Administration Technical Bulletin 10-94, December 1, 1953. Google Scholar7. Denny-BrownSciarra DD: Changes in the nervous system in acute porphyria; 2 cases, Brain 68: 1, 1945. CrossrefGoogle Scholar8. Dean G: Porphyria, Brit. M. J. 2: 1291, 1953. CrossrefMedlineGoogle Scholar9. WatsonLarson CJEA: The urinary coproporphyrins in health and disease, Physiol. Rev. 27: 478, 1947. CrossrefMedlineGoogle Scholar10. RaskHowell EWH: The photodynamic action of hematoporphyrin, Am. J. Physiol. 84: 363, 1928. CrossrefGoogle Scholar11. ReitlingerKlee KP: Zur biologischen Wirkung der Porphyrine, Arch. f. exper. Path. u. Pharmakol. 127: 277, 1928. CrossrefGoogle Scholar12. 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WatsonLarson CJEA: The porphyrias and their relation to disease; porphyria, in Christian's Oxford medicine, 1949, Oxford University Press, New York, p. 228 (1). Google Scholar29. BakerWatson ABCJ: The central nervous system in porphyria, J. Neuropath. and Exper. Neurol. 4: 68, 1945. CrossrefGoogle Scholar30. MasonCourvilleZiskind VRCE: The porphyrins in human disease, Medicine 12: 355, 1933. CrossrefGoogle Scholar31. Gordin R: Prostigmin vid akut porfyri, Nord. med. 37: 480, 1948. MedlineGoogle Scholar32. GillhespySmith ROSG: Porphyria treated with neostigmine, Lancet 1: 908, 1954. CrossrefGoogle Scholar33. Wilson JA: Porphyria treated with neostigmine, Lancet 1: 1134, 1954. CrossrefGoogle Scholar34. FreedmanYeagleyBrooks AJDJB: Acute porphyria with improvement during and following pregnancy, Ann. Int. Med. 36: 1111, 1952. LinkGoogle Scholar35. JanoffPoutasYoung LAJJD: Acute intermittent porphyria; prompt response to therapy with corticotropin, Arch. Int. Med. 91: 389, 1953. CrossrefGoogle Scholar36. OltmanFriedman JES: Acute porphyria, New England J. Med. 244: 173, 1951. CrossrefGoogle Scholar37. Olmstead EG: The neuropsychiatric aspects of abnormal porphyrin metabolism, J. Nerv. and Ment. Dis. 117: 300, 1953. CrossrefMedlineGoogle Scholar38. VisherAldrich JSCK: Acute intermittent porphyria; a case study, Psychosom. Med. 16: 163, 1954. CrossrefMedlineGoogle Scholar39. Calvy GL: Porphyria; a consideration in surgical diagnosis, Surg., Gynec. and Obst. 90: 716, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication November 29, 1954.From the Division of Medicine (Metabolic Section), Brooklyn Veterans Administration Hospital, Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiovascular SystemPORPHYRIA CUTANEA TARDA SYMPTOMATICA ASSOCIATED WITH HEPATIC GRANULOMATAHepatic porphyria with pancreatic involvementPossible Aggravation of Abdominal Symptoms by Tolbutamide in a Patient with Diabetes and Hepatic PorphyriaAcute porphyria 1 February 1956Volume 44, Issue 2Page: 391-406KeywordsAdrenocorticotropic hormoneAlcoholsCalciumDiabetes mellitusHospital medicineHypertensionInsulinPathogenesisPorphyriaPyelonephritis ePublished: 1 December 2008 Issue Published: 1 February 1956 PDF downloadLoading ..." @default.
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