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• W1547492751 abstract "The concept of gene therapy is defined as a biomedical technology to treat diseases with functional genes or therapeutic genes by transferring these genes into cells. According to the most comprehensive source of information on worldwide gene therapy clinical trials available on the internet from “The Journal of Gene Medicine” clinical trial site (http://www.wiley.com/genmed/clinical), there are 1060 clinical trials (64.5%) for cancer treatment among the total 1644 trials updated June 2010, and most of them (23.8%) use adenovirus as vector. However, gene therapy goes through one of gains and losses since the very day of its naissance. Until late 2009, gene therapy received a series of great achievements after years of silence. The journal, Science, appraised 10 breakthroughs of the Year 2009, in which the seventh was gene therapy. It brings us a rekindled hope for overcoming the genetic diseases including cancer. Adenoviral vectors have been used extensively in cancer gene therapy (Su et al., 2008; Yang et al., 2007). Most of them are replication-deficient (Yang, 1995). The first generated replication-deficient adenovirus lacks the E1 and E3 regions. The second and third ones also contain E2 and/or E4 deletions (Andrews et al., 2001; Thomas et al., 2003). Because the replication-deficient adenoviruses can not replicate, they express the foreign therapeutic genes only in the cells that are initially infected. Synchronously, they also lack a specificity target to cancer cells (Kurihara et al., 2000). These problems may decrease the therapeutic effect on cancer cells and result in toxicity to normal cells. Therefore, development of a novel tumor-targeting adenoviral vector is needed to enhance the efficiency and specificity of transgene expression. Oncolytic adenoviruses are promising as therapeutic agents in cancer treatment. These viruses are genetically modified to target, infect and replicate in cancer cells causing them to lyse with an improved, superior efficacy compared to non-replicating adenoviral vector which lacks the E1 genes. Here, combined with the studies of our group (Fang et al., 2009, 2010; He et al., 2009, 2010; Hu et al., 2010; Ma et al., 2009; Su et al., 2004, 2006a, 2006b, 2008a, 2008b), we review the development of oncolytic adenovirus-based gene therapy for cancer, and figured the potential prospects of gene therapy in cancer treatment." @default.
• W1547492751 created "2016-06-24" @default.
• W1547492751 creator A5010613321 @default.
• W1547492751 date "2011-07-20" @default.
• W1547492751 modified "2023-09-23" @default.
• W1547492751 title "Adenovirus-Based Gene Therapy for Cancer" @default.
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