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- W1547630086 endingPage "298" @default.
- W1547630086 startingPage "272" @default.
- W1547630086 abstract "This chapter focuses on postsynthetic oligonucleotide modifications. It reviews the methods used to introduce reactive groups into nucleotides by solid phase synthesis (SPS), enzymatic polymerization, and enzymatic ligation. The chapter explains the covalent modifications of functionalized oligonucleotides. It introduces analytical techniques for characterization of modified nucleic acids. There are two main strategies for preparing covalent nucleic acids conjugates: the presynthetic and the postsynthetic labeling. Any covalent modification of nucleic acids ideally has to proceed in water for solubility, under mild conditions to avoid denaturations, and using relatively low concentrations of reactants to ensure high chemoselectivity. Postsynthetic labeling steps have been reported to proceed in anhydrous DMF after sodium to triethylammonium counterion metathesis for oligonucleotide solubilization. In the past few years, new bioorthogonal reactions have been developed or adapted for covalent oligonucleotides labeling by the post-synthetic approach." @default.
- W1547630086 created "2016-06-24" @default.
- W1547630086 creator A5025487971 @default.
- W1547630086 creator A5058899747 @default.
- W1547630086 date "2014-10-31" @default.
- W1547630086 modified "2023-10-17" @default.
- W1547630086 title "Covalent Organic Functionalization of Nucleic Acids" @default.
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