FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1547748619> ?p ?o ?g. }

• W1547748619 endingPage "243" @default.
• W1547748619 startingPage "227" @default.
• W1547748619 abstract "The following peptides were synthesized by classical methods in solution: Ac-Gly-Gly- Val-Arg-Gly-Pro-Arg-Val-Val-Glu-Arg-NHCH3 (A), Ac-Ala-Glu-Gly-Gly-Gly-Val- Arg-Gly-Pro-Arg-Val-Val-Glu-Arg-NHCH3 (B), and Ac-Phe-Leu-Ala-Glu-Gly-Gly- Gly-Val-Arg-Gly-Pro-Arg-Val-Val-Glu-Arg-NHCH3 (C). The rates of hydrolysis of the Arg-Gly bond of these three peptides by thrombin were measured, and the values of kcatKm were found to be 0.05 × 10−7 (A), 0.02 × 10−7 (B), and 1.6 × 10−7 (C) [(NIH units/ liter)s]−1. The value ofkcatKm for peptide C is less than 1% of that for fibrinogen [although the value of kcat itself, for peptide C (but not for A or B), is comparable to that for fibrinogen]. These results indicate that phenylanine and leucine at positions P9 and P8, respectively, play a key role in the reaction of thrombin with fibrinogen. The data also show that factors outside of the 16 residues of peptide C are important in determining the rate of hydrolysis of fibrogen by thrombin." @default.
• W1547748619 created "2016-06-24" @default.
• W1547748619 creator A5047719714 @default.
• W1547748619 creator A5054151562 @default.
• W1547748619 creator A5057404758 @default.
• W1547748619 date "1977-07-01" @default.
• W1547748619 modified "2023-09-27" @default.
• W1547748619 title "Mechanism of action of thrombin on fibrinogen" @default.
• W1547748619 cites W1480621060 @default.
• W1547748619 cites W1482359667 @default.
• W1547748619 cites W1510927739 @default.
• W1547748619 cites W1530598475 @default.
• W1547748619 cites W1562590055 @default.
• W1547748619 cites W1610057614 @default.
• W1547748619 cites W1822405509 @default.
• W1547748619 cites W1963625808 @default.
• W1547748619 cites W1976253224 @default.
• W1547748619 cites W1985469117 @default.
• W1547748619 cites W1985683436 @default.
• W1547748619 cites W2005673848 @default.
• W1547748619 cites W2011847957 @default.
• W1547748619 cites W2015432612 @default.
• W1547748619 cites W2025385906 @default.
• W1547748619 cites W2026853898 @default.
• W1547748619 cites W2030768172 @default.
• W1547748619 cites W2044557749 @default.
• W1547748619 cites W2051754095 @default.
• W1547748619 cites W2055468500 @default.
• W1547748619 cites W2058170465 @default.
• W1547748619 cites W2058727757 @default.
• W1547748619 cites W2059678898 @default.
• W1547748619 cites W2066388064 @default.
• W1547748619 cites W2075009329 @default.
• W1547748619 cites W2077639256 @default.
• W1547748619 cites W2085188000 @default.
• W1547748619 cites W2087298783 @default.
• W1547748619 cites W2090139847 @default.
• W1547748619 cites W2098432632 @default.
• W1547748619 cites W2112864356 @default.
• W1547748619 cites W2114291124 @default.
• W1547748619 cites W2128148658 @default.
• W1547748619 cites W2128809047 @default.
• W1547748619 cites W2134389598 @default.
• W1547748619 cites W2135625467 @default.
• W1547748619 cites W2149718646 @default.
• W1547748619 cites W2320558242 @default.
• W1547748619 cites W2322344246 @default.
• W1547748619 cites W2331879018 @default.
• W1547748619 cites W3210499822 @default.
• W1547748619 cites W4244048148 @default.
• W1547748619 doi "https://doi.org/10.1016/0003-9861(77)90303-4" @default.
• W1547748619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/560822" @default.
• W1547748619 hasPublicationYear "1977" @default.
• W1547748619 type Work @default.
• W1547748619 sameAs 1547748619 @default.
• W1547748619 citedByCount "39" @default.
• W1547748619 countsByYear W15477486192021 @default.
• W1547748619 crossrefType "journal-article" @default.
• W1547748619 hasAuthorship W1547748619A5047719714 @default.
• W1547748619 hasAuthorship W1547748619A5054151562 @default.
• W1547748619 hasAuthorship W1547748619A5057404758 @default.
• W1547748619 hasConcept C126322002 @default.
• W1547748619 hasConcept C181199279 @default.
• W1547748619 hasConcept C185592680 @default.
• W1547748619 hasConcept C2776580952 @default.
• W1547748619 hasConcept C2777292125 @default.
• W1547748619 hasConcept C2779036427 @default.
• W1547748619 hasConcept C2779281246 @default.
• W1547748619 hasConcept C41183919 @default.
• W1547748619 hasConcept C515207424 @default.
• W1547748619 hasConcept C55493867 @default.
• W1547748619 hasConcept C56856141 @default.
• W1547748619 hasConcept C71240020 @default.
• W1547748619 hasConcept C71924100 @default.
• W1547748619 hasConcept C89560881 @default.
• W1547748619 hasConcept C94412978 @default.
• W1547748619 hasConceptScore W1547748619C126322002 @default.
• W1547748619 hasConceptScore W1547748619C181199279 @default.
• W1547748619 hasConceptScore W1547748619C185592680 @default.
• W1547748619 hasConceptScore W1547748619C2776580952 @default.
• W1547748619 hasConceptScore W1547748619C2777292125 @default.
• W1547748619 hasConceptScore W1547748619C2779036427 @default.
• W1547748619 hasConceptScore W1547748619C2779281246 @default.
• W1547748619 hasConceptScore W1547748619C41183919 @default.
• W1547748619 hasConceptScore W1547748619C515207424 @default.
• W1547748619 hasConceptScore W1547748619C55493867 @default.
• W1547748619 hasConceptScore W1547748619C56856141 @default.
• W1547748619 hasConceptScore W1547748619C71240020 @default.
• W1547748619 hasConceptScore W1547748619C71924100 @default.
• W1547748619 hasConceptScore W1547748619C89560881 @default.
• W1547748619 hasConceptScore W1547748619C94412978 @default.
• W1547748619 hasIssue "1" @default.
• W1547748619 hasLocation W15477486191 @default.
• W1547748619 hasLocation W15477486192 @default.
• W1547748619 hasOpenAccess W1547748619 @default.
• W1547748619 hasPrimaryLocation W15477486191 @default.
• W1547748619 hasRelatedWork W1991234816 @default.
• W1547748619 hasRelatedWork W2047139495 @default.

• next