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- W1547750236 abstract "Abstract Nude (nu/nu) mice, which lack the thymus, failed to produce an immune response to various antigens. When such animals were injected intravenously with normal thymus cells, lasting immune responsiveness was restored only if the cells came from animals “related” to the nude recipients. The required relationship was probably H-2 compatibility. An allotype marker was used to determine the specificity of the antibody-producing cells. Even after a period of 12 weeks the antibody produced was entirely of host cell type. No evidence that thymus cells may develop into antibody-producing cells was found." @default.
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- W1547750236 date "1971-11-01" @default.
- W1547750236 modified "2023-10-14" @default.
- W1547750236 title "Antibody Response in Genetically Thymus-Less Nude Mice Injected with Normal Thymus Cells" @default.
- W1547750236 doi "https://doi.org/10.4049/jimmunol.107.5.1291" @default.
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