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- W1547872020 abstract "To study right and left ventricular (RV, LV) long axis function (LAF) in fetuses with complete transposition of great arteries (TGA) using M-mode. Retrospective study: 12 fetuses with TGA, 12 with normal hearts, matched for gestational age (GA). RV and LV LAF was assessed by two observers (48 images), blinded to diagnosis (TGA/controls), GA and if RV or LV. Maximal displacement of tricuspid or mitral valve was measured electronically, the average of 3 values used for analysis. Normality was assessed by Shapiro Will test; groups were compared using paired t-test and intra-class correlation (ICC) was used for variability analysis. Intra-observer variability: ICC = 0.99 (95% CI 0.99–1.00) for RV and 0.92 (95% CI 0.83–0.97) for LV. Inter-observer variability: ICC = 0.96 (95% CI 0.91–0.98) for RV and 0.96 (95% CI 0.90–0.987) for LV. Mean difference between RV and LV LAF in TGA group was 0.21 cm (95% CI 0.08 to 0.33) P = 0.004 and in controls, 0.17 cm (95% CI 0.09 to 0.24) P < 0.001. Comparison of RV LAF between TGA and controls showed mean difference of 0.06 cm (95% CI − 0.05 to 0.18) P = 0.26. Comparison of LV LAF in TGA and controls was 0.02 cm (95% CI − 0.08 to 0.12) P = 0.66. Post-hoc power analysis based on the observed difference (RV LAF), n = 12 for each group, alpha = 0.05, shows the study to be underpowered. LAF is reproducible, with good intra- and inter-observer agreement. Preliminary observations are encouraging and suggest that biventricular LAF may be preserved in fetuses with TGA, despite a change in afterload." @default.
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- W1547872020 date "2012-09-01" @default.
- W1547872020 modified "2023-10-05" @default.
- W1547872020 title "OP27.09: Ventricular long axis function in fetuses with complete transposition: preliminary observations of a pilot study" @default.
- W1547872020 doi "https://doi.org/10.1002/uog.11655" @default.
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