FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1548013483> ?p ?o ?g. }

• W1548013483 endingPage "6614" @default.
• W1548013483 startingPage "6603" @default.
• W1548013483 abstract "The B and T lymphocyte attenuator (BTLA) is a recently identified member of the CD28 family of cell receptors. Initial reports demonstrated that mice deficient in BTLA expression were more susceptible to experimental autoimmune encephalomyelitis, indicating that BTLA was likely to function as a negative regulator of T cell activation. However, cross-linking of BTLA only resulted in a 2-fold reduction of IL-2 production, questioning the potency with which BTLA engagement blocks T cell activation. We established a model in which BTLA signaling could be studied in primary human CD4 T cells. We observed that cross-linking of a chimeric receptor consisting of the murine CD28 extracellular domain and human BTLA cytoplasmic tail potently inhibits IL-2 production and completely suppresses T cell expansion. Mutation of any BTLA tyrosine motifs had no effect on the ability of BTLA to block T cell activation. Only mutation of all four tyrosines rendered the BTLA cytoplasmic tail nonfunctional. We performed structure-function studies to determine which factors recruited to the BTLA cytoplasmic tail correlated with BTLA function. Using pervanadate as a means to phosphorylate the BTLA cytoplasmic tail, we observed both Src homology protein (SHP)-1 and SHP-2 recruitment. However, upon receptor engagement, we observed only SHP-1 recruitment, and mutations that abrogated SHP-1 recruitment did not impair BTLA function. These studies question whether SHP-1 or SHP-2 have any role in BTLA function and caution against the use of pervanadate as means to initiate signal transduction cascades in primary cells." @default.
• W1548013483 created "2016-06-24" @default.
• W1548013483 creator A5007142646 @default.
• W1548013483 creator A5011336649 @default.
• W1548013483 creator A5017210717 @default.
• W1548013483 creator A5091567901 @default.
• W1548013483 date "2006-05-18" @default.
• W1548013483 modified "2023-10-10" @default.
• W1548013483 title "B and T Lymphocyte Attenuator-Mediated Signal Transduction Provides a Potent Inhibitory Signal to Primary Human CD4 T Cells That Can Be Initiated by Multiple Phosphotyrosine Motifs" @default.
• W1548013483 cites W1510108058 @default.
• W1548013483 cites W1513178664 @default.
• W1548013483 cites W1528343050 @default.
• W1548013483 cites W1613752608 @default.
• W1548013483 cites W1655422333 @default.
• W1548013483 cites W1664485198 @default.
• W1548013483 cites W1898621392 @default.
• W1548013483 cites W1914550558 @default.
• W1548013483 cites W193563991 @default.
• W1548013483 cites W1951252517 @default.
• W1548013483 cites W1964203957 @default.
• W1548013483 cites W1965955513 @default.
• W1548013483 cites W1966930760 @default.
• W1548013483 cites W1967090173 @default.
• W1548013483 cites W1970746962 @default.
• W1548013483 cites W1974806850 @default.
• W1548013483 cites W1975735851 @default.
• W1548013483 cites W1988890993 @default.
• W1548013483 cites W1992184534 @default.
• W1548013483 cites W1994688157 @default.
• W1548013483 cites W1995539779 @default.
• W1548013483 cites W2001716606 @default.
• W1548013483 cites W2004023501 @default.
• W1548013483 cites W2012972418 @default.
• W1548013483 cites W2016983859 @default.
• W1548013483 cites W2025471328 @default.
• W1548013483 cites W2026376882 @default.
• W1548013483 cites W2029101596 @default.
• W1548013483 cites W2029855686 @default.
• W1548013483 cites W2036150733 @default.
• W1548013483 cites W2037279230 @default.
• W1548013483 cites W2045039830 @default.
• W1548013483 cites W2049030343 @default.
• W1548013483 cites W2049557514 @default.
• W1548013483 cites W2055143049 @default.
• W1548013483 cites W2055248228 @default.
• W1548013483 cites W2056535502 @default.
• W1548013483 cites W2063264144 @default.
• W1548013483 cites W2067188588 @default.
• W1548013483 cites W2071177946 @default.
• W1548013483 cites W2086397613 @default.
• W1548013483 cites W2087104707 @default.
• W1548013483 cites W2088313410 @default.
• W1548013483 cites W2095434093 @default.
• W1548013483 cites W2098853737 @default.
• W1548013483 cites W2100265029 @default.
• W1548013483 cites W2103228630 @default.
• W1548013483 cites W2103532863 @default.
• W1548013483 cites W2107322032 @default.
• W1548013483 cites W2108885062 @default.
• W1548013483 cites W2111811086 @default.
• W1548013483 cites W2113765407 @default.
• W1548013483 cites W2118705059 @default.
• W1548013483 cites W2121498145 @default.
• W1548013483 cites W2130506153 @default.
• W1548013483 cites W2134143263 @default.
• W1548013483 cites W2134372981 @default.
• W1548013483 cites W2138421443 @default.
• W1548013483 cites W2149748445 @default.
• W1548013483 cites W2151157466 @default.
• W1548013483 cites W2152812674 @default.
• W1548013483 cites W2156268588 @default.
• W1548013483 cites W2165610297 @default.
• W1548013483 cites W2404064356 @default.
• W1548013483 cites W4250196117 @default.
• W1548013483 cites W425633012 @default.
• W1548013483 doi "https://doi.org/10.4049/jimmunol.176.11.6603" @default.
• W1548013483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16709818" @default.
• W1548013483 hasPublicationYear "2006" @default.
• W1548013483 type Work @default.
• W1548013483 sameAs 1548013483 @default.
• W1548013483 citedByCount "70" @default.
• W1548013483 countsByYear W15480134832012 @default.
• W1548013483 countsByYear W15480134832013 @default.
• W1548013483 countsByYear W15480134832014 @default.
• W1548013483 countsByYear W15480134832015 @default.
• W1548013483 countsByYear W15480134832016 @default.
• W1548013483 countsByYear W15480134832017 @default.
• W1548013483 countsByYear W15480134832018 @default.
• W1548013483 countsByYear W15480134832019 @default.
• W1548013483 countsByYear W15480134832020 @default.
• W1548013483 countsByYear W15480134832021 @default.
• W1548013483 countsByYear W15480134832022 @default.
• W1548013483 countsByYear W15480134832023 @default.
• W1548013483 crossrefType "journal-article" @default.
• W1548013483 hasAuthorship W1548013483A5007142646 @default.
• W1548013483 hasAuthorship W1548013483A5011336649 @default.
• W1548013483 hasAuthorship W1548013483A5017210717 @default.
• W1548013483 hasAuthorship W1548013483A5091567901 @default.

• next