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- W1548077440 abstract "Several medical products of natural origin were conceived in traditional systems of knowledge and practice that has been transmitted over centuries and which continuously change. In actual scenario, researchers of many countries involved in the modern drug discovery processes are becoming increasingly aware of the value of their traditional knowledge, while global pharmaceutical industry is looking for alternative solutions to reduce the crescent innovation deficit and enhance the development of new products. Has been systematically showed that aleatory screening of plants used traditionally by pharmaceutical industries in the search for new leads or drugs is vastly expensive and requires much time. On the other hand, ethnodirected approach to traditional knowledge has been extremely useful in screening and identification of plants with bioactive compounds with potential application in drug development. This approach consists in selecting species according to the indication of specific population groups in certain contexts of use. The ethnodirected approach has significantly increased the chances of discovery of new biomolecules with potential therapeutic application while reduce the cost and time involved in this process. Beyond this approach provide a shortcut to the discovery of active compounds that could serve as a basis for rational drug development, it also provides a mechanism for pre-screening on the therapeutic properties of the species collected. Most of these compounds are part of routinely used traditional medicines and hence their tolerance and safety are relatively better known than any other chemical entities that are new for human use. Thus, traditional medicine based on ethnodirected bioprospecting offers an unmatched structural variety as promising new leads. In the context of ethnodirected studies, the ethnopharmacological research has shown a great contribution in selecting plants and discovery of compounds with pharmacological potential. Ethnopharmacology is a strategy used in the investigation of plants with medicinal properties, combining information acquired from users of medicinal plants (traditional communities and experts), with chemical and pharmacological studies. While in the past the typical industrial drug discovery process made the use of aleatory selection and systematic bioassays to find promising compounds for a particular target," @default.
- W1548077440 created "2016-06-24" @default.
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- W1548077440 date "2011-11-04" @default.
- W1548077440 modified "2023-10-18" @default.
- W1548077440 title "Ethnopharmacology as Current Strategy in the Search of Novel Anti-Ulcerogenic Drugs: Case of a Brazilian Medicinal Plant (Maytenus ilicifolia Mart. ex. Reissek)" @default.
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- W1548077440 doi "https://doi.org/10.5772/19663" @default.
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