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• W1548157089 abstract "Pediatric Blood & CancerVolume 61, Issue 10 p. 1717-1718 Highlight The promises and pitfalls of genetic epidemiologic approaches to pediatric cancers: Lessons from MDM2 Lee D. McDaniel MS, Lee D. McDaniel MS Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abramson Family Cancer Research Institute, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PennsylvaniaSearch for more papers by this authorJohn M. Maris MD, Corresponding Author John M. Maris MD Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abramson Family Cancer Research Institute, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania Correspondence to: John M. Maris, Children's Hospital of Philadelphia, Colket Translational Research Building 3060, 3501 Civic Center Boulevard, Philadelphia, PA 19104-4318. E-mail: [email protected]Search for more papers by this author Lee D. McDaniel MS, Lee D. McDaniel MS Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abramson Family Cancer Research Institute, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PennsylvaniaSearch for more papers by this authorJohn M. Maris MD, Corresponding Author John M. Maris MD Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abramson Family Cancer Research Institute, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania Correspondence to: John M. Maris, Children's Hospital of Philadelphia, Colket Translational Research Building 3060, 3501 Civic Center Boulevard, Philadelphia, PA 19104-4318. E-mail: [email protected]Search for more papers by this author First published: 17 June 2014 https://doi.org/10.1002/pbc.25051Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1 Bond GL, Hu W, Bond EE, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004; 119: 591– 602. 2 Bougeard G, Baert-Desurmont S, Tournier I, et al. Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li–Fraumeni syndrome. J Med Genet 2006; 43: 531– 533. 3 Cattelani S, Defferrari R, Marsilio S, et al. Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: Results of a pilot study on 239 patients. Clin Cancer Res 2008; 14: 3248– 3253. 4 Perfumo C, Parodi S, Mazzocco K, et al. Impact of MDM2 SNP309 genotype on progression and survival of stage 4 neuroblastoma. Eur J Cancer 2008; 44: 2634– 2639. 5 Perfumo C, Parodi S, Mazzocco K, et al. MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma. Pediatr Blood Cancer 2009; 53: 576– 583. 6 Parodi S, Perfumo C, Garaventa A, et al. MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma. Pediatr Blood Cancer 2010; 55: 267– 272. 7 Rihani A, Van Maerken T, De Wilde B, et al. Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma. Pediatr Blood Cancer 2014. 8 Nuzzo R. Scientific method: Statistical errors. Nature 2014; 506: 150– 152. 9 Wang K, Diskin SJ, Zhang H, et al. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature 2011; 469: 216– 220. 10 Maris JM, Mosse YP, Bradfield JP, et al. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med 2008; 358: 2585– 2593. 11 Diskin SJ, Capasso M, Schnepp RW, et al. Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet 2012; 44: 1126– 1130. Volume61, Issue10October 2014Pages 1717-1718 ReferencesRelatedInformation" @default.
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• W1548157089 title "The promises and pitfalls of genetic epidemiologic approaches to pediatric cancers: Lessons from MDM2" @default.
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