FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1548653314> ?p ?o ?g. }

• W1548653314 endingPage "156" @default.
• W1548653314 startingPage "139" @default.
• W1548653314 abstract "The seminal discovery that cytochrome P450 enzymes (CYPs) can oxidize polyunsaturated fatty acids (PUFAs) sparked a new area of research aimed at discovering the role of these metabolites in cardiac physiology and pathophysiology. CYPs metabolize arachidonic acid, an ω-6 PUFA, to alcohols and epoxides with the latter providing cardioprotection following myocardial infarction, hypertrophy, and diabetes-induced cardiomyopathy through their anti-inflammatory, vasodilatory and antioxidant properties. Despite their protective properties, the use of EETs as therapeutic agents is hampered mainly by their rapid hydrolysis to less active vicinal diols by soluble epoxide hydrolase (sEH). Several approaches have been investigated to prolong EET signaling effects using small molecule sEH inhibitors, chemically and biologically stable analogs of EETs and more recently, through the development of an sEH vaccine. Alternatively, research investigating the cardioprotective outcomes of ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), mainly focused on dietary intake or supplementation studies. EPA and DHA have overlapping but distinct effects on myocardial function and merit separate studies to fully understand their mechanism of cardiac protection. In contrast to EETs, relatively fewer studies examined the protective mechanisms of EPA and DHA derived epoxides to determine if some protective effects are in part due to the CYP mediated downstream metabolites. The actions of CYPs on PUFAs generate potent oxylipins utilizing diverse cardioprotective mechanisms and the extent of their full potential will be important for the future development of therapeutics to prevent or treat cardiovascular disease." @default.
• W1548653314 created "2016-06-24" @default.
• W1548653314 creator A5025677580 @default.
• W1548653314 creator A5083015210 @default.
• W1548653314 date "1995-10-01" @default.
• W1548653314 modified "2023-10-15" @default.
• W1548653314 title "Prostaglandin endoperoxide synthases-1 and -2" @default.
• W1548653314 cites W1480527955 @default.
• W1548653314 cites W1485442945 @default.
• W1548653314 cites W1488753908 @default.
• W1548653314 cites W1490087754 @default.
• W1548653314 cites W1490609633 @default.
• W1548653314 cites W1514928695 @default.
• W1548653314 cites W1525772448 @default.
• W1548653314 cites W1527453674 @default.
• W1548653314 cites W1529632581 @default.
• W1548653314 cites W1531513729 @default.
• W1548653314 cites W1536031017 @default.
• W1548653314 cites W1536681507 @default.
• W1548653314 cites W1540849804 @default.
• W1548653314 cites W1555602949 @default.
• W1548653314 cites W1563962170 @default.
• W1548653314 cites W1575557511 @default.
• W1548653314 cites W1579134710 @default.
• W1548653314 cites W1583142517 @default.
• W1548653314 cites W1587123510 @default.
• W1548653314 cites W1591927171 @default.
• W1548653314 cites W1594730050 @default.
• W1548653314 cites W1596000517 @default.
• W1548653314 cites W1601845527 @default.
• W1548653314 cites W1607633625 @default.
• W1548653314 cites W1659584317 @default.
• W1548653314 cites W1660326086 @default.
• W1548653314 cites W1669371681 @default.
• W1548653314 cites W1674582945 @default.
• W1548653314 cites W1740416844 @default.
• W1548653314 cites W1856590789 @default.
• W1548653314 cites W1902547891 @default.
• W1548653314 cites W1966183396 @default.
• W1548653314 cites W1966358461 @default.
• W1548653314 cites W1973504278 @default.
• W1548653314 cites W1981092612 @default.
• W1548653314 cites W1982273085 @default.
• W1548653314 cites W1982558048 @default.
• W1548653314 cites W1988086603 @default.
• W1548653314 cites W1997739078 @default.
• W1548653314 cites W1998973642 @default.
• W1548653314 cites W2001692633 @default.
• W1548653314 cites W2003599597 @default.
• W1548653314 cites W2003719859 @default.
• W1548653314 cites W2008424322 @default.
• W1548653314 cites W2025325421 @default.
• W1548653314 cites W2026457555 @default.
• W1548653314 cites W2026628125 @default.
• W1548653314 cites W2027216583 @default.
• W1548653314 cites W2029059069 @default.
• W1548653314 cites W2034679499 @default.
• W1548653314 cites W2036620657 @default.
• W1548653314 cites W2039473230 @default.
• W1548653314 cites W2063144963 @default.
• W1548653314 cites W2075731485 @default.
• W1548653314 cites W2078666052 @default.
• W1548653314 cites W2084526185 @default.
• W1548653314 cites W2086996966 @default.
• W1548653314 cites W2087537112 @default.
• W1548653314 cites W2094066863 @default.
• W1548653314 cites W2094752831 @default.
• W1548653314 cites W2107359522 @default.
• W1548653314 cites W2115350007 @default.
• W1548653314 cites W2139979263 @default.
• W1548653314 cites W2139988779 @default.
• W1548653314 cites W2146605723 @default.
• W1548653314 cites W2894728782 @default.
• W1548653314 cites W2952136017 @default.
• W1548653314 cites W58296940 @default.
• W1548653314 doi "https://doi.org/10.1016/0929-7855(95)00015-i" @default.
• W1548653314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8777562" @default.
• W1548653314 hasPublicationYear "1995" @default.
• W1548653314 type Work @default.
• W1548653314 sameAs 1548653314 @default.
• W1548653314 citedByCount "177" @default.
• W1548653314 countsByYear W15486533142012 @default.
• W1548653314 countsByYear W15486533142013 @default.
• W1548653314 countsByYear W15486533142014 @default.
• W1548653314 countsByYear W15486533142015 @default.
• W1548653314 countsByYear W15486533142016 @default.
• W1548653314 countsByYear W15486533142017 @default.
• W1548653314 countsByYear W15486533142018 @default.
• W1548653314 countsByYear W15486533142019 @default.
• W1548653314 countsByYear W15486533142020 @default.
• W1548653314 countsByYear W15486533142021 @default.
• W1548653314 countsByYear W15486533142022 @default.
• W1548653314 countsByYear W15486533142023 @default.
• W1548653314 crossrefType "journal-article" @default.
• W1548653314 hasAuthorship W1548653314A5025677580 @default.
• W1548653314 hasAuthorship W1548653314A5083015210 @default.
• W1548653314 hasConcept C126322002 @default.
• W1548653314 hasConcept C181199279 @default.

• next