FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1548772785> ?p ?o ?g. }

• W1548772785 abstract "Lactic acid and short chain fatty acids (SCFAs) produced by vaginal microbiota have reported antimicrobial and immune modulatory activities indicating their potential as biomarkers of disease and/or disease susceptibility. In asymptomatic women of reproductive-age the vaginal microbiota is comprised of lactic acid-producing bacteria that are primarily responsible for the production of lactic acid present at ~110 mM and acidifying the vaginal milieu to pH ~3.5. In contrast, bacterial vaginosis (BV), a dysbiosis of the vaginal microbiota, is characterized by decreased lactic acid-producing microbiota and increased diverse anaerobic bacteria accompanied by an elevated pH>4.5. BV is also characterized by a dramatic loss of lactic acid and greater concentrations of mixed SCFAs including acetate, propionate, butyrate, and succinate. Notably women with lactic acid-producing microbiota have more favorable reproductive and sexual health outcomes compared to women with BV. Regarding the latter, BV is associated with increased susceptibility to sexually transmitted infections (STIs) including HIV. In vitro studies demonstrate that lactic acid produced by vaginal microbiota has microbicidal and virucidal activities that may protect against STIs and endogenous opportunistic bacteria as well as immune modulatory properties that require further characterization with regard to their effects on the vaginal mucosa. In contrast, BV-associated SCFAs have far less antimicrobial activity with the potential to contribute to a pro-inflammatory vaginal environment. Here we review the composition of lactic acid and SCFAs in respective states of eubiosis (non-BV) or dysbiosis (BV), their effects on susceptibility to bacterial/viral STIs and whether they have inherent microbicidal/virucidal and immune modulatory properties. We also explore their potential as biomarkers for the presence and/or increased susceptibility to STIs." @default.
• W1548772785 created "2016-06-24" @default.
• W1548772785 creator A5002285957 @default.
• W1548772785 creator A5010366287 @default.
• W1548772785 creator A5021248144 @default.
• W1548772785 creator A5023574039 @default.
• W1548772785 creator A5036388659 @default.
• W1548772785 creator A5045316156 @default.
• W1548772785 creator A5058392069 @default.
• W1548772785 creator A5091161981 @default.
• W1548772785 date "2015-06-02" @default.
• W1548772785 modified "2023-10-13" @default.
• W1548772785 title "Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis" @default.
• W1548772785 cites W1511490662 @default.
• W1548772785 cites W1517638146 @default.
• W1548772785 cites W1521770510 @default.
• W1548772785 cites W1547082834 @default.
• W1548772785 cites W1555109673 @default.
• W1548772785 cites W1556211525 @default.
• W1548772785 cites W1560846896 @default.
• W1548772785 cites W1636224414 @default.
• W1548772785 cites W1754047185 @default.
• W1548772785 cites W1764884642 @default.
• W1548772785 cites W1765618930 @default.
• W1548772785 cites W1783060902 @default.
• W1548772785 cites W1868667984 @default.
• W1548772785 cites W1899317453 @default.
• W1548772785 cites W1921707153 @default.
• W1548772785 cites W1942676613 @default.
• W1548772785 cites W1946133036 @default.
• W1548772785 cites W1964788094 @default.
• W1548772785 cites W1965615399 @default.
• W1548772785 cites W1966546381 @default.
• W1548772785 cites W1966918442 @default.
• W1548772785 cites W1968312831 @default.
• W1548772785 cites W1968670250 @default.
• W1548772785 cites W1972528270 @default.
• W1548772785 cites W1974399308 @default.
• W1548772785 cites W1976777633 @default.
• W1548772785 cites W1977179183 @default.
• W1548772785 cites W1977183377 @default.
• W1548772785 cites W1978607717 @default.
• W1548772785 cites W1979742728 @default.
• W1548772785 cites W1980015141 @default.
• W1548772785 cites W1980028864 @default.
• W1548772785 cites W1981116426 @default.
• W1548772785 cites W1982013562 @default.
• W1548772785 cites W1983683595 @default.
• W1548772785 cites W1984895921 @default.
• W1548772785 cites W1984980172 @default.
• W1548772785 cites W1986029856 @default.
• W1548772785 cites W1986272998 @default.
• W1548772785 cites W1986372050 @default.
• W1548772785 cites W1986590728 @default.
• W1548772785 cites W1986940747 @default.
• W1548772785 cites W1989704399 @default.
• W1548772785 cites W1991566442 @default.
• W1548772785 cites W1991933056 @default.
• W1548772785 cites W1992823394 @default.
• W1548772785 cites W1992833126 @default.
• W1548772785 cites W1993241533 @default.
• W1548772785 cites W1996776107 @default.
• W1548772785 cites W1999906527 @default.
• W1548772785 cites W2000241141 @default.
• W1548772785 cites W2001624986 @default.
• W1548772785 cites W2002574877 @default.
• W1548772785 cites W2003342633 @default.
• W1548772785 cites W2004684513 @default.
• W1548772785 cites W2004809144 @default.
• W1548772785 cites W2005295131 @default.
• W1548772785 cites W2006752090 @default.
• W1548772785 cites W2009599544 @default.
• W1548772785 cites W2010572285 @default.
• W1548772785 cites W2011707350 @default.
• W1548772785 cites W2013371150 @default.
• W1548772785 cites W2013553461 @default.
• W1548772785 cites W2014605450 @default.
• W1548772785 cites W2017153096 @default.
• W1548772785 cites W2017525816 @default.
• W1548772785 cites W2018420111 @default.
• W1548772785 cites W2018703522 @default.
• W1548772785 cites W2020549361 @default.
• W1548772785 cites W2020694416 @default.
• W1548772785 cites W2022074240 @default.
• W1548772785 cites W2022107632 @default.
• W1548772785 cites W2022111190 @default.
• W1548772785 cites W2023330864 @default.
• W1548772785 cites W2025922599 @default.
• W1548772785 cites W2027112591 @default.
• W1548772785 cites W2027143713 @default.
• W1548772785 cites W2027297424 @default.
• W1548772785 cites W2027378590 @default.
• W1548772785 cites W2027548763 @default.
• W1548772785 cites W2027596874 @default.
• W1548772785 cites W2028605145 @default.
• W1548772785 cites W2028835702 @default.
• W1548772785 cites W2030920585 @default.
• W1548772785 cites W2031894451 @default.
• W1548772785 cites W2031935259 @default.
• W1548772785 cites W2032523448 @default.

• next