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• W1548924670 abstract "ABSTRACT Initiation of herpesvirus infection requires attachment of virions to the host cell followed by fusion of virion envelope and cellular cytoplasmic membrane during penetration. In several alphaherpesviruses, glycoprotein C (gC) is the primary attachment protein, interacting with cell-surface heparan sulfate proteoglycans. Secondary binding is mediated by gD, which, normally, is also required for penetration. Recently, we described the isolation of a gD-negative infectious pseudorabies virus (PrV) mutant, PrV gD − Pass (J. Schmidt, B. G. Klupp, A. Karger, and T. C. Mettenleiter, J. Virol. 71:17–24, 1997). In PrV gD − Pass, attachment and penetration occur in the absence of gD. To assess the importance of specific attachment for infectivity of PrV gD − Pass, the gene encoding gC was deleted, resulting in mutant PrV gCD − Pass. Deletion of both known attachment proteins reduced specific infectivity compared to wild-type PrV by more than 10,000-fold. Surprisingly, the virus mutant still retained significant infectivity and could be propagated on normal noncomplementing cells, indicating the presence of another receptor-binding virion protein. Selection of bovine kidney (MDBK) cells resistant to infection by PrV gCD − Pass resulted in the isolation of a cell clone, designated NB, which was susceptible to infection by wild-type PrV but refractory to infection by either PrV gCD − Pass or PrV gD − Pass, a defect which could partially be overcome by polyethylene glycol (PEG)-induced membrane fusion. However, even after PEG-induced infection plaque formation of PrV gCD − Pass or PrV gD − Pass did not ensue in NB cells. Also, phenotypic gD complementation of PrV gCD − Pass or PrV gD − Pass rescued the defect in infection of NB cells but did not restore plaque formation. Glycosaminoglycan analyses of MDBK and NB cells yielded identical results, and NB cells were normally susceptible to infection by other alphaherpesviruses as well as vesicular stomatitis virus. Infectious center assays after PEG-induced infection of NB cells with PrV gD − Pass on MDBK cells indicated efficient exit of virions from infected NB cells. Together, our data suggest the presence of another receptor and receptor-binding virion protein which can mediate PrV entry and cell-to-cell spread in MDBK cells." @default.
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• W1548924670 date "1998-09-01" @default.
• W1548924670 modified "2023-10-16" @default.
• W1548924670 title "Infectivity of a Pseudorabies Virus Mutant Lacking Attachment Glycoproteins C and D" @default.
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• W1548924670 doi "https://doi.org/10.1128/jvi.72.9.7341-7348.1998" @default.
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