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- W154898139 abstract "The study of the anatomic and physiologic organization of circadian systems of invertebrates has a long and productive history. Modern research can be traced to the work of Janet Harker in the 1950s, who initiated efforts to localize pacemakers and photoreceptors of the circadian system of the cockroach via lesion and transplantation studies. Ultimately, Harker was not successful, but the questions and approaches she pioneered set the stage for subsequent efforts to identify components of invertebrate circadian systems. These efforts have been directed toward answering several fundamental questions about the organization of the circadian system which are the focus of this review. The first of these concerns the nature of the pacemaking system that generates the timing signal. What are the anatomic loci of component oscillators, what is the significance of multioscillator organization, and how does the pacemaking system emerge in development? Second, what are the pathways and mechanisms by which inputs to the pacemaking system regulate its phase and period? Finally, what are the neural and endocrine signals by which the pacemaking system regulates the various processes under its control?" @default.
- W154898139 created "2016-06-24" @default.
- W154898139 creator A5023173735 @default.
- W154898139 date "2001-01-01" @default.
- W154898139 modified "2023-09-27" @default.
- W154898139 title "Circadian Systems of Invertebrates" @default.
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