FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549011111> ?p ?o ?g. }

• W1549011111 endingPage "385" @default.
• W1549011111 startingPage "372" @default.
• W1549011111 abstract "Metastasis to the brain is frequent in adult cancer patients but rare among children. Advances in primary tumor treatment and the associated prolonged survival are said to have increased the frequency of brain metastasis in children. The authors present a series of cases of brain metastases in children diagnosed with a solid primary cancer, evaluate brain metastasis trends, and describe tumor type, patterns of occurrence, and prognosis.Patients with brain metastases whose primary cancer was diagnosed during childhood were identified in the 1990-2012 Tumor Registry at The University of Texas M.D. Anderson Cancer Center. A review of their hospital records provided demographic data, history, and clinical data, including primary cancer sites, number and location of brain metastases, sites of extracranial metastases, treatments, and outcomes.Fifty-four pediatric patients (1.4%) had a brain metastasis from a solid primary tumor. Sarcomas were the most common (54%), followed by melanoma (15%). The patients' median ages at diagnosis of the primary cancer and the brain metastasis were 11.37 years and 15.03 years, respectively. The primary cancer was localized at diagnosis in 48% of patients and disseminated regionally in only 14%. The primary tumor and brain metastasis presented synchronously in 15% of patients, and other extracranial metastases were present when the primary cancer was diagnosed. The remaining patients were diagnosed with brain metastasis after initiation of primary cancer treatment, with a median presentation interval of 17 months after primary cancer diagnosis (range 2-77 months). At the time of diagnosis, the brain metastasis was the first site of systemic metastasis in only 4 (8%) of the 51 patients for whom data were available. Up to 70% of patients had lung metastases when brain metastases were found. Symptoms led to the brain metastasis diagnosis in 65% of cases. Brain metastases were single in 60% of cases and multiple in 35%; 6% had only leptomeningeal disease. The median Kaplan-Meier estimates of survival after diagnoses of primary cancer and brain metastasis were 29 months (95% CI 24-34 months) and 9 months (95% CI 6-11 months), respectively. Untreated patients survived for a median of 0.9 months after brain metastasis diagnosis (95% CI 0.3-1.5 months). Those receiving treatment survived for a median of 8 months after initiation of therapy (95% CI 6-11 months).The results of this study challenge the current notion of an increased incidence of brain metastases among children with a solid primary cancer. The earlier diagnosis of the primary cancer, prior to its dissemination to distant sites (especially the brain), and initiation of presumably more effective treatments may support such an observation. However, although the actual number of cases may not be increasing, the prognosis after the diagnosis of a brain metastasis remains poor regardless of the management strategy." @default.
• W1549011111 created "2016-06-24" @default.
• W1549011111 creator A5008540539 @default.
• W1549011111 creator A5010522454 @default.
• W1549011111 creator A5024356241 @default.
• W1549011111 creator A5069609591 @default.
• W1549011111 creator A5091806633 @default.
• W1549011111 date "2014-10-01" @default.
• W1549011111 modified "2023-10-01" @default.
• W1549011111 title "Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center" @default.
• W1549011111 cites W1919080085 @default.
• W1549011111 cites W1968937232 @default.
• W1549011111 cites W1969180882 @default.
• W1549011111 cites W1985093335 @default.
• W1549011111 cites W1994231575 @default.
• W1549011111 cites W2007879593 @default.
• W1549011111 cites W2022842927 @default.
• W1549011111 cites W2026151282 @default.
• W1549011111 cites W2026427373 @default.
• W1549011111 cites W2039547677 @default.
• W1549011111 cites W2071542599 @default.
• W1549011111 cites W2071897976 @default.
• W1549011111 cites W2072827813 @default.
• W1549011111 cites W2075946118 @default.
• W1549011111 cites W2082065488 @default.
• W1549011111 cites W2082586394 @default.
• W1549011111 cites W2085161885 @default.
• W1549011111 cites W2087839764 @default.
• W1549011111 cites W2087896886 @default.
• W1549011111 cites W2106254921 @default.
• W1549011111 cites W2140608134 @default.
• W1549011111 cites W2169790456 @default.
• W1549011111 cites W2207539183 @default.
• W1549011111 cites W4294553434 @default.
• W1549011111 cites W4296289652 @default.
• W1549011111 doi "https://doi.org/10.3171/2014.7.peds13318" @default.
• W1549011111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25127097" @default.
• W1549011111 hasPublicationYear "2014" @default.
• W1549011111 type Work @default.
• W1549011111 sameAs 1549011111 @default.
• W1549011111 citedByCount "25" @default.
• W1549011111 countsByYear W15490111112015 @default.
• W1549011111 countsByYear W15490111112017 @default.
• W1549011111 countsByYear W15490111112018 @default.
• W1549011111 countsByYear W15490111112019 @default.
• W1549011111 countsByYear W15490111112020 @default.
• W1549011111 countsByYear W15490111112021 @default.
• W1549011111 countsByYear W15490111112022 @default.
• W1549011111 countsByYear W15490111112023 @default.
• W1549011111 crossrefType "journal-article" @default.
• W1549011111 hasAuthorship W1549011111A5008540539 @default.
• W1549011111 hasAuthorship W1549011111A5010522454 @default.
• W1549011111 hasAuthorship W1549011111A5024356241 @default.
• W1549011111 hasAuthorship W1549011111A5069609591 @default.
• W1549011111 hasAuthorship W1549011111A5091806633 @default.
• W1549011111 hasConcept C121608353 @default.
• W1549011111 hasConcept C126322002 @default.
• W1549011111 hasConcept C142724271 @default.
• W1549011111 hasConcept C143998085 @default.
• W1549011111 hasConcept C2777658100 @default.
• W1549011111 hasConcept C2778164965 @default.
• W1549011111 hasConcept C2778527826 @default.
• W1549011111 hasConcept C2779013556 @default.
• W1549011111 hasConcept C2779130545 @default.
• W1549011111 hasConcept C2780283643 @default.
• W1549011111 hasConcept C502942594 @default.
• W1549011111 hasConcept C71924100 @default.
• W1549011111 hasConceptScore W1549011111C121608353 @default.
• W1549011111 hasConceptScore W1549011111C126322002 @default.
• W1549011111 hasConceptScore W1549011111C142724271 @default.
• W1549011111 hasConceptScore W1549011111C143998085 @default.
• W1549011111 hasConceptScore W1549011111C2777658100 @default.
• W1549011111 hasConceptScore W1549011111C2778164965 @default.
• W1549011111 hasConceptScore W1549011111C2778527826 @default.
• W1549011111 hasConceptScore W1549011111C2779013556 @default.
• W1549011111 hasConceptScore W1549011111C2779130545 @default.
• W1549011111 hasConceptScore W1549011111C2780283643 @default.
• W1549011111 hasConceptScore W1549011111C502942594 @default.
• W1549011111 hasConceptScore W1549011111C71924100 @default.
• W1549011111 hasIssue "4" @default.
• W1549011111 hasLocation W15490111111 @default.
• W1549011111 hasLocation W15490111112 @default.
• W1549011111 hasOpenAccess W1549011111 @default.
• W1549011111 hasPrimaryLocation W15490111111 @default.
• W1549011111 hasRelatedWork W2046078271 @default.
• W1549011111 hasRelatedWork W2055887390 @default.
• W1549011111 hasRelatedWork W2059910543 @default.
• W1549011111 hasRelatedWork W2095263706 @default.
• W1549011111 hasRelatedWork W2102978104 @default.
• W1549011111 hasRelatedWork W2126431105 @default.
• W1549011111 hasRelatedWork W2323529144 @default.
• W1549011111 hasRelatedWork W2403319043 @default.
• W1549011111 hasRelatedWork W2420616379 @default.
• W1549011111 hasRelatedWork W4225326932 @default.
• W1549011111 hasVolume "14" @default.
• W1549011111 isParatext "false" @default.
• W1549011111 isRetracted "false" @default.
• W1549011111 magId "1549011111" @default.

• next