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- W1549031975 abstract "This chapter discusses a physiologically and biophysically rich model system for endogenous calcium-activated Cl channel in Xenopus oocytes. The Xenopus oocyte Ca(Cl) channel is the flagship member of the Ca-activated Cl channel family because it is well characterized on a physiological and biophysical level. This channel should be used as a benchmark for comparing other Ca-activated Cl channels. Some mammalian Cl(Ca) channels closely resemble the Xenopus oocyte channel, whereas others are decidedly different. The Cl(Ca) channel has the interesting feature that its sensitivity to Ca2+ is voltage sensitive. The channel is less sensitive to Ca 2+ at hyperpolarized potentials than at depolarized potentials. This apparent voltage-dependent affinity of the channel for Ca 2+ results from the voltage dependence of the closing reaction. In the Xenopus egg, sperm entry during fertilization turns on Cl(Ca) channels as a consequence of Ca 2+ release from internal stores. By opening these channels, it produces the fertilization potential to prevent polyspermy." @default.
- W1549031975 created "2016-06-24" @default.
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- W1549031975 creator A5085462187 @default.
- W1549031975 date "2002-01-01" @default.
- W1549031975 modified "2023-10-12" @default.
- W1549031975 title "The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system" @default.
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