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- W1549084953 abstract "Imipramine hydrochloride shows effects in a battery of tests used for the screening of antidepressant drugs. The central origin of these pharmacological effects of imipramine has not been clearly established. Imipramine methiodide is a quaternary derivative of imipramine which does not cross the blood-brain barrier easily. The effects of the two forms of imipramine have been compared: (1) on an effect known to have a central origin; (2) on two effects known to have a peripheral origin; (3) on a battery of tests used for the screening of antidepressant drugs. It has been demonstrated that imipramine methiodide is as active as imipramine hydrochloride on two effects of peripheral origin, less active than imipramine hydrochloride on an effect considered to have a central origin and less active than imipramine hydrochloride or inactive on the tests which are used for the screening of antidepressant drugs. Consequently, the tests used for the screening of antidepressant drugs represent, primarily or exclusively, effects of central origin." @default.
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- W1549084953 date "1985-07-01" @default.
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- W1549084953 title "Comparison of imipramine-imipraminium in mice" @default.
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- W1549084953 doi "https://doi.org/10.1016/0028-3908(85)90109-1" @default.
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