FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549199866> ?p ?o ?g. }

• W1549199866 endingPage "3247" @default.
• W1549199866 startingPage "3239" @default.
• W1549199866 abstract "To identify new genetic associations with juvenile and adult dermatomyositis (DM).We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM.Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P < 5 × 10(-8)) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of <0.05. These genes were phospholipase C-like 1 (PLCL1; rs6738825, FDR = 0.00089), B lymphoid tyrosine kinase (BLK; rs2736340, FDR = 0.0031), and chemokine (C-C motif) ligand 21 (CCL21; rs951005, FDR = 0.0076). None of these genes was previously reported to be associated with DM.Our findings confirm the MHC as the major genetic region associated with DM and indicate that DM shares non-MHC genetic features with other autoimmune diseases, suggesting the presence of additional novel risk loci. This first identification of autoimmune disease genetic predispositions shared with DM may lead to enhanced understanding of pathogenesis and novel diagnostic and therapeutic approaches." @default.
• W1549199866 created "2016-06-24" @default.
• W1549199866 creator A5005014098 @default.
• W1549199866 creator A5006243024 @default.
• W1549199866 creator A5007214574 @default.
• W1549199866 creator A5007817213 @default.
• W1549199866 creator A5008098676 @default.
• W1549199866 creator A5008843939 @default.
• W1549199866 creator A5010330353 @default.
• W1549199866 creator A5012584139 @default.
• W1549199866 creator A5012718828 @default.
• W1549199866 creator A5017541508 @default.
• W1549199866 creator A5018005178 @default.
• W1549199866 creator A5025424500 @default.
• W1549199866 creator A5028989565 @default.
• W1549199866 creator A5037338479 @default.
• W1549199866 creator A5040273759 @default.
• W1549199866 creator A5041302124 @default.
• W1549199866 creator A5046727318 @default.
• W1549199866 creator A5054223849 @default.
• W1549199866 creator A5055609688 @default.
• W1549199866 creator A5056507445 @default.
• W1549199866 creator A5065207114 @default.
• W1549199866 creator A5065779609 @default.
• W1549199866 creator A5065798696 @default.
• W1549199866 creator A5066232855 @default.
• W1549199866 creator A5075818510 @default.
• W1549199866 creator A5078240641 @default.
• W1549199866 creator A5079921904 @default.
• W1549199866 creator A5080625220 @default.
• W1549199866 creator A5082248535 @default.
• W1549199866 creator A5090959009 @default.
• W1549199866 date "2013-11-27" @default.
• W1549199866 modified "2023-10-17" @default.
• W1549199866 title "Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders" @default.
• W1549199866 cites W1915010695 @default.
• W1549199866 cites W1963639770 @default.
• W1549199866 cites W1972985967 @default.
• W1549199866 cites W1973139179 @default.
• W1549199866 cites W1988821153 @default.
• W1549199866 cites W2006603427 @default.
• W1549199866 cites W2018249504 @default.
• W1549199866 cites W2024108088 @default.
• W1549199866 cites W2026475357 @default.
• W1549199866 cites W2026615227 @default.
• W1549199866 cites W2042342193 @default.
• W1549199866 cites W2060227777 @default.
• W1549199866 cites W2062680329 @default.
• W1549199866 cites W2067119828 @default.
• W1549199866 cites W2072664252 @default.
• W1549199866 cites W2077905727 @default.
• W1549199866 cites W2090019626 @default.
• W1549199866 cites W2094619835 @default.
• W1549199866 cites W2096095753 @default.
• W1549199866 cites W2099978636 @default.
• W1549199866 cites W2101790075 @default.
• W1549199866 cites W2106779017 @default.
• W1549199866 cites W2106928918 @default.
• W1549199866 cites W2112409097 @default.
• W1549199866 cites W2115441215 @default.
• W1549199866 cites W2115783720 @default.
• W1549199866 cites W2118705425 @default.
• W1549199866 cites W2132402446 @default.
• W1549199866 cites W2154656443 @default.
• W1549199866 cites W2156787360 @default.
• W1549199866 cites W2161633633 @default.
• W1549199866 cites W2161967080 @default.
• W1549199866 cites W2164064529 @default.
• W1549199866 cites W2164278527 @default.
• W1549199866 cites W2165872127 @default.
• W1549199866 cites W2166768418 @default.
• W1549199866 cites W2168578952 @default.
• W1549199866 cites W4240806480 @default.
• W1549199866 doi "https://doi.org/10.1002/art.38137" @default.
• W1549199866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3934004" @default.
• W1549199866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23983088" @default.
• W1549199866 hasPublicationYear "2013" @default.
• W1549199866 type Work @default.
• W1549199866 sameAs 1549199866 @default.
• W1549199866 citedByCount "109" @default.
• W1549199866 countsByYear W15491998662013 @default.
• W1549199866 countsByYear W15491998662014 @default.
• W1549199866 countsByYear W15491998662015 @default.
• W1549199866 countsByYear W15491998662016 @default.
• W1549199866 countsByYear W15491998662017 @default.
• W1549199866 countsByYear W15491998662018 @default.
• W1549199866 countsByYear W15491998662019 @default.
• W1549199866 countsByYear W15491998662020 @default.
• W1549199866 countsByYear W15491998662021 @default.
• W1549199866 countsByYear W15491998662022 @default.
• W1549199866 countsByYear W15491998662023 @default.
• W1549199866 crossrefType "journal-article" @default.
• W1549199866 hasAuthorship W1549199866A5005014098 @default.
• W1549199866 hasAuthorship W1549199866A5006243024 @default.
• W1549199866 hasAuthorship W1549199866A5007214574 @default.
• W1549199866 hasAuthorship W1549199866A5007817213 @default.
• W1549199866 hasAuthorship W1549199866A5008098676 @default.
• W1549199866 hasAuthorship W1549199866A5008843939 @default.

• next