FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W154920662> ?p ?o ?g. }

• W154920662 endingPage "735" @default.
• W154920662 startingPage "725" @default.
• W154920662 abstract "Burkholderia pseudomallei, the causative agent of melioidosis, is an intracellular pathogen capable of invading and multiplying in both phagocytic and non-phagocytic cells. Infection results in an inflammatory response involving production of both pro- and anti-inflammatory cytokines. The cellular mechanism regulating this response, believed to play an important role in the pathogenesis of meliodoisis, is not fully understood. In recent years, glycogen synthase kinase-3 (GSK3) has been shown to assume a pivotal role in regulating production of these cytokines. Bacterial infection of host cells activates Toll-like receptors (TLRs) and results in the phosphorylation of GSK3β through activation of the phosphoinositide 3-kinase (PI3K) pathway. In this study, we investigated the effects of GSK3 inhibition in regulating B. pseudomallei-induced inflammatory response in macrophages and A549 epithelial lung cells. Our results showed that infection of cells with B. pseudomallei resulted in the increase of anti-inflammatory cytokine, IL-10 and pro-inflammatory cytokine, TNF-α. Pre-treatment of infected cells with GSK3 inhibitors caused further increase in the level of IL-10 but a significant decrease in TNF-α. These changes corresponded with the detection of phosphorylated GSK3β in infected cells treated with LiCl; suggesting that modulation of inflammatory response in B. pseudomallei infection involves phosphorylation of GSK3β (Ser 9). This could explain our observations from the invasion assays that pre-treatment of B. pseudomallei-infected cells with GSK3 inhibitors resulted in decreased intracellular replication of bacteria within macrophages and A549 epithelial lung cells. In summary, our results demonstrate a regulatory function of GSK3 in the modulation of cytokine levels during B. pseudomallei infection." @default.
• W154920662 created "2016-06-24" @default.
• W154920662 creator A5008487255 @default.
• W154920662 creator A5008907765 @default.
• W154920662 creator A5063635715 @default.
• W154920662 creator A5067115688 @default.
• W154920662 creator A5079395765 @default.
• W154920662 date "2013-06-01" @default.
• W154920662 modified "2023-09-23" @default.
• W154920662 title "Inhibition of GSK3 attenuates the intracellular multiplication of burkholderia pseudomallei and modulates the inflammatory response in infected macrophages and A549 epithelial lung cells" @default.
• W154920662 cites W1496316111 @default.
• W154920662 cites W1568605582 @default.
• W154920662 cites W1586370436 @default.
• W154920662 cites W1656968650 @default.
• W154920662 cites W1896084611 @default.
• W154920662 cites W1965591002 @default.
• W154920662 cites W1974950953 @default.
• W154920662 cites W1975454216 @default.
• W154920662 cites W1980767418 @default.
• W154920662 cites W1985542681 @default.
• W154920662 cites W1996976561 @default.
• W154920662 cites W2000193859 @default.
• W154920662 cites W2003035812 @default.
• W154920662 cites W2009231148 @default.
• W154920662 cites W2018328223 @default.
• W154920662 cites W2019800572 @default.
• W154920662 cites W2032081895 @default.
• W154920662 cites W2042181517 @default.
• W154920662 cites W2048656742 @default.
• W154920662 cites W2057855290 @default.
• W154920662 cites W2062934426 @default.
• W154920662 cites W2063381646 @default.
• W154920662 cites W2063631483 @default.
• W154920662 cites W2064962037 @default.
• W154920662 cites W2069089745 @default.
• W154920662 cites W2071081142 @default.
• W154920662 cites W2076962381 @default.
• W154920662 cites W2078427654 @default.
• W154920662 cites W2079439457 @default.
• W154920662 cites W2081706555 @default.
• W154920662 cites W2086860754 @default.
• W154920662 cites W2088072579 @default.
• W154920662 cites W2091819001 @default.
• W154920662 cites W2102911609 @default.
• W154920662 cites W2111469080 @default.
• W154920662 cites W2116798307 @default.
• W154920662 cites W2152994693 @default.
• W154920662 cites W2156275638 @default.
• W154920662 cites W2166660370 @default.
• W154920662 cites W2168007983 @default.
• W154920662 cites W2172029859 @default.
• W154920662 cites W2758003236 @default.
• W154920662 cites W31581040 @default.
• W154920662 cites W2181941840 @default.
• W154920662 hasPublicationYear "2013" @default.
• W154920662 type Work @default.
• W154920662 sameAs 154920662 @default.
• W154920662 citedByCount "2" @default.
• W154920662 countsByYear W1549206622015 @default.
• W154920662 crossrefType "journal-article" @default.
• W154920662 hasAuthorship W154920662A5008487255 @default.
• W154920662 hasAuthorship W154920662A5008907765 @default.
• W154920662 hasAuthorship W154920662A5063635715 @default.
• W154920662 hasAuthorship W154920662A5067115688 @default.
• W154920662 hasAuthorship W154920662A5079395765 @default.
• W154920662 hasConcept C164027704 @default.
• W154920662 hasConcept C17991360 @default.
• W154920662 hasConcept C190283241 @default.
• W154920662 hasConcept C203014093 @default.
• W154920662 hasConcept C2776914184 @default.
• W154920662 hasConcept C2778690821 @default.
• W154920662 hasConcept C2779110727 @default.
• W154920662 hasConcept C2779775996 @default.
• W154920662 hasConcept C523546767 @default.
• W154920662 hasConcept C54355233 @default.
• W154920662 hasConcept C55493867 @default.
• W154920662 hasConcept C79879829 @default.
• W154920662 hasConcept C81729549 @default.
• W154920662 hasConcept C86803240 @default.
• W154920662 hasConcept C89423630 @default.
• W154920662 hasConcept C95444343 @default.
• W154920662 hasConceptScore W154920662C164027704 @default.
• W154920662 hasConceptScore W154920662C17991360 @default.
• W154920662 hasConceptScore W154920662C190283241 @default.
• W154920662 hasConceptScore W154920662C203014093 @default.
• W154920662 hasConceptScore W154920662C2776914184 @default.
• W154920662 hasConceptScore W154920662C2778690821 @default.
• W154920662 hasConceptScore W154920662C2779110727 @default.
• W154920662 hasConceptScore W154920662C2779775996 @default.
• W154920662 hasConceptScore W154920662C523546767 @default.
• W154920662 hasConceptScore W154920662C54355233 @default.
• W154920662 hasConceptScore W154920662C55493867 @default.
• W154920662 hasConceptScore W154920662C79879829 @default.
• W154920662 hasConceptScore W154920662C81729549 @default.
• W154920662 hasConceptScore W154920662C86803240 @default.
• W154920662 hasConceptScore W154920662C89423630 @default.
• W154920662 hasConceptScore W154920662C95444343 @default.
• W154920662 hasIssue "6" @default.

• next