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- W1549212895 abstract "Intense exercise results in increases in intracellular Na+ and extracellular K+ concentrations, leading to depolarization and a loss of muscle excitability and contractility. Here, we use carbacholine to chronically activate the nicotinic acetylcholine (nACh) receptors to mimic the changes in membrane permeability, chemical Na+ and K+ gradients and membrane potential observed during intense exercise. Intact rat soleus muscles were mounted on force transducers and stimulated electrically to evoke short tetani at regular intervals. Carbacholine produced a 2.6-fold increase in Na+ influx that was tetrodotoxin (TTX) insensitive, but abolished by tubocurarine, resulting in a significant 36% increase in intracellular Na+, and 8% decrease in intracellular K+ content. The mid region, near the motor end plate, had much larger alterations than the more distal regions of the muscle, and showed a larger membrane depolarization from −73 ± 1 to −60 ± 1 mV compared with −64 ± 1 mV. Carbacholine (10−4m) significantly reduced tetanic force to 31 ± 3% of controls, which underwent significant recovery upon application of Na+–K+ pump stimulators: salbutamol (10−5m), adrenaline (10−5m) and calcitonin gene-related peptide (CGRP; 10−7m). The force recovery with salbutamol was accompanied by a recovery of intracellular Na+ and K+ contents, and a small but significant 4–5 mV recovery of membrane potential. Similar results were obtained using succinylcholine (10−4m), indicating that Na+–K+ pump stimulation may prevent or restore succinylcholine-induced hyperkalaemia. The stimulation of the Na+–K+ pump allows muscle to partially recover contractility by regaining excitability through electrogenically driven repolarization of the muscle membrane." @default.
- W1549212895 created "2016-06-24" @default.
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- W1549212895 creator A5025198074 @default.
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- W1549212895 date "2005-02-21" @default.
- W1549212895 modified "2023-10-18" @default.
- W1549212895 title "Na+-K+pump stimulation restores carbacholine-induced loss of excitability and contractility in rat skeletal muscle" @default.
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- W1549212895 doi "https://doi.org/10.1113/jphysiol.2004.080390" @default.
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