Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549274675> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1549274675 endingPage "3172" @default.
- W1549274675 startingPage "3162" @default.
- W1549274675 abstract "Abstract We have previously reported the identification, using human immune sera, of mimotopes of human hepatitis B virus surface Ag (HBsAg) displayed on filamentous phage. To test if these mimotopes could be useful in developing a vaccine against the human hepatitis B virus (HBV), we have compared the humoral immune response of animals immunized either with a recombinant HBsAg vaccine, or with mimotopes. Immunogens were prepared by fusing the mimotopes on different carrier molecules (phage coat protein pIII and pVIII, recombinant human H ferritin, HBV core peptide) and by synthesizing multiple antigenic peptides carrying the mimotopes' amino acid sequences. These immunogens were injected into mice and rabbits and sera were collected and tested for the presence of HBsAg-specific Abs. Our data confirm that mimotopes can induce a humoral immune response resembling that induced by the original Ag, and HBsAg mimotopes displayed on phage prove to be the best immunogens, inducing the most reproducible and potent immunization. Mimotopes that react as HBV subtype-specific Ags do not show this specificity as immunogen and induce a nonsubtype-restricted response. Furthermore, mimotopes displayed on phage elicit a strong response to HBsAg in a strain of mouse reported to show a low response to it. These results indicate that mimotopes identified from random peptide libraries through utilizing human immune sera could be important leads for the derivation of new vaccines." @default.
- W1549274675 created "2016-06-24" @default.
- W1549274675 creator A5003267441 @default.
- W1549274675 creator A5022640226 @default.
- W1549274675 creator A5037606727 @default.
- W1549274675 creator A5052004438 @default.
- W1549274675 creator A5054172216 @default.
- W1549274675 creator A5070702245 @default.
- W1549274675 creator A5074741886 @default.
- W1549274675 creator A5082450967 @default.
- W1549274675 date "1995-04-01" @default.
- W1549274675 modified "2023-10-17" @default.
- W1549274675 title "Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage." @default.
- W1549274675 doi "https://doi.org/10.4049/jimmunol.154.7.3162" @default.
- W1549274675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7534789" @default.
- W1549274675 hasPublicationYear "1995" @default.
- W1549274675 type Work @default.
- W1549274675 sameAs 1549274675 @default.
- W1549274675 citedByCount "111" @default.
- W1549274675 countsByYear W15492746752012 @default.
- W1549274675 countsByYear W15492746752013 @default.
- W1549274675 countsByYear W15492746752014 @default.
- W1549274675 countsByYear W15492746752015 @default.
- W1549274675 countsByYear W15492746752016 @default.
- W1549274675 countsByYear W15492746752017 @default.
- W1549274675 countsByYear W15492746752021 @default.
- W1549274675 countsByYear W15492746752022 @default.
- W1549274675 countsByYear W15492746752023 @default.
- W1549274675 crossrefType "journal-article" @default.
- W1549274675 hasAuthorship W1549274675A5003267441 @default.
- W1549274675 hasAuthorship W1549274675A5022640226 @default.
- W1549274675 hasAuthorship W1549274675A5037606727 @default.
- W1549274675 hasAuthorship W1549274675A5052004438 @default.
- W1549274675 hasAuthorship W1549274675A5054172216 @default.
- W1549274675 hasAuthorship W1549274675A5070702245 @default.
- W1549274675 hasAuthorship W1549274675A5074741886 @default.
- W1549274675 hasAuthorship W1549274675A5082450967 @default.
- W1549274675 hasBestOaLocation W15492746751 @default.
- W1549274675 hasConcept C104317684 @default.
- W1549274675 hasConcept C147483822 @default.
- W1549274675 hasConcept C159047783 @default.
- W1549274675 hasConcept C159654299 @default.
- W1549274675 hasConcept C186268636 @default.
- W1549274675 hasConcept C195616568 @default.
- W1549274675 hasConcept C203014093 @default.
- W1549274675 hasConcept C2522874641 @default.
- W1549274675 hasConcept C2777410769 @default.
- W1549274675 hasConcept C2779909307 @default.
- W1549274675 hasConcept C2780593183 @default.
- W1549274675 hasConcept C2780801004 @default.
- W1549274675 hasConcept C40767141 @default.
- W1549274675 hasConcept C542903549 @default.
- W1549274675 hasConcept C55493867 @default.
- W1549274675 hasConcept C86803240 @default.
- W1549274675 hasConcept C8891405 @default.
- W1549274675 hasConcept C9365378 @default.
- W1549274675 hasConceptScore W1549274675C104317684 @default.
- W1549274675 hasConceptScore W1549274675C147483822 @default.
- W1549274675 hasConceptScore W1549274675C159047783 @default.
- W1549274675 hasConceptScore W1549274675C159654299 @default.
- W1549274675 hasConceptScore W1549274675C186268636 @default.
- W1549274675 hasConceptScore W1549274675C195616568 @default.
- W1549274675 hasConceptScore W1549274675C203014093 @default.
- W1549274675 hasConceptScore W1549274675C2522874641 @default.
- W1549274675 hasConceptScore W1549274675C2777410769 @default.
- W1549274675 hasConceptScore W1549274675C2779909307 @default.
- W1549274675 hasConceptScore W1549274675C2780593183 @default.
- W1549274675 hasConceptScore W1549274675C2780801004 @default.
- W1549274675 hasConceptScore W1549274675C40767141 @default.
- W1549274675 hasConceptScore W1549274675C542903549 @default.
- W1549274675 hasConceptScore W1549274675C55493867 @default.
- W1549274675 hasConceptScore W1549274675C86803240 @default.
- W1549274675 hasConceptScore W1549274675C8891405 @default.
- W1549274675 hasConceptScore W1549274675C9365378 @default.
- W1549274675 hasIssue "7" @default.
- W1549274675 hasLocation W15492746751 @default.
- W1549274675 hasLocation W15492746752 @default.
- W1549274675 hasOpenAccess W1549274675 @default.
- W1549274675 hasPrimaryLocation W15492746751 @default.
- W1549274675 hasRelatedWork W155863482 @default.
- W1549274675 hasRelatedWork W1998808386 @default.
- W1549274675 hasRelatedWork W1999964620 @default.
- W1549274675 hasRelatedWork W2031210994 @default.
- W1549274675 hasRelatedWork W2058381089 @default.
- W1549274675 hasRelatedWork W2073771134 @default.
- W1549274675 hasRelatedWork W2123232740 @default.
- W1549274675 hasRelatedWork W2351417972 @default.
- W1549274675 hasRelatedWork W2391198628 @default.
- W1549274675 hasRelatedWork W3133690536 @default.
- W1549274675 hasVolume "154" @default.
- W1549274675 isParatext "false" @default.
- W1549274675 isRetracted "false" @default.
- W1549274675 magId "1549274675" @default.
- W1549274675 workType "article" @default.