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• W1549369814 endingPage "5248" @default.
• W1549369814 startingPage "5240" @default.
• W1549369814 abstract "T cell immune responses are regulated by the interplay between effector and suppressor T cells. Immunization with Ag leads to the selective expansion and survival of effector CD4(+) T cells with high affinity TCR against the Ag and MHC. However, it is not known if CD4(+)CD25(+) regulatory T cells (T(reg)) recognize the same Ag as effector T cells or whether Ag-specific TCR repertoire modification occurs in T(reg). In this study, we demonstrate that after a primary Ag challenge, T(reg) proliferate and TCR repertoire modification is observed although both of these responses were lower than those in conventional T cells. The repertoire modification of Ag-specific T(reg) after primary Ag challenge augmented the total suppressive function of T(reg) against TCR repertoire modification but not against the proliferation of memory CD4(+) T cells. These results reveal that T cell repertoire modification against a non-self Ag occurs in T(reg), which would be crucial for limiting excess primary and memory CD4(+) T cell responses. In addition, these studies provide evidence that manipulation of Ag-specific T(reg) is an ideal strategy for the clinical use of T(reg)." @default.
• W1549369814 created "2016-06-24" @default.
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• W1549369814 date "2004-05-01" @default.
• W1549369814 modified "2023-10-11" @default.
• W1549369814 title "Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells" @default.
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• W1549369814 doi "https://doi.org/10.4049/jimmunol.172.9.5240" @default.
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