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• W1549389235 startingPage "5852" @default.
• W1549389235 abstract "Our previous studies in volunteers immunized with Salmonella enterica serovar Typhi (S. Typhi) have suggested an important role for CD8+ T cells in host defense. In this study we describe a novel subset of nonclassical human HLA-E-restricted S. Typhi-specific CD8+ T cells derived from PBMC of Ty21a typhoid vaccinees. CD3+CD8+CD4-CD56- T cells effectively killed S. Typhi-infected targets regardless of whether they share classical HLA class I molecules with them, by a FAS-independent, granule-dependent mechanism, as evidenced by induction of granzyme B release and the blocking effects of concanamycin and strontium ions. The expression of HLA-E Ags, but not CD1-a, -b, or -c, on the membrane of S. Typhi-infected targets rendered them susceptible to lysis. Moreover, anti-HLA-E Abs partially blocked these responses. We also demonstrated that presentation of S. Typhi Ags via HLA-E could stimulate IFN-gamma production. Increases in the net frequency of IFN-gamma spot-forming cells were observed in the presence of targets coated with peptides that contain S. Typhi GroEL HLA-E binding motifs. These results demonstrate that HLA-E binds nonamer peptides derived from bacterial proteins and trigger CD8+-mediated lysis and IFN-gamma production when exposed to infected targets, raising the possibility that this novel effector mechanism might contribute to host defense against intracellular bacterial infections." @default.
• W1549389235 created "2016-06-24" @default.
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• W1549389235 date "2004-10-19" @default.
• W1549389235 modified "2023-10-17" @default.
• W1549389235 title "Identification of a Human HLA-E-Restricted CD8⁺ T Cell Subset in Volunteers Immunized with <i>Salmonella enterica</i> Serovar Typhi Strain Ty21a Typhoid Vaccine" @default.
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• W1549389235 doi "https://doi.org/10.4049/jimmunol.173.9.5852" @default.
• W1549389235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15494539" @default.
• W1549389235 hasPublicationYear "2004" @default.
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