FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549553625> ?p ?o ?g. }

• W1549553625 endingPage "35" @default.
• W1549553625 startingPage "625" @default.
• W1549553625 abstract "The serine/threonine protein kinase NIMA of Aspergillus nidulans is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Here, we report the isolation of complementary DNAs encoding Nek2 and Nek3, two novel human protein kinases structurally related to NIMA. Sequence comparisons revealed several unique features which may define a family of NIMA-related protein kinases. Nek2 was chosen for further study since it represents the closest known mammalian relative of NIMA. Chromosomal mapping of the nek2 gene identified two independent loci on chromosomes 1 and 14, and Northern blot analyses revealed the expression of two distinct mRNAs of approximately 2.4 and 4.7 kilobases in all human cell lines examined. In HeLa cells synchronized by both drug arrest and elutriation, a strikingly cell cycle-dependent pattern of Nek2 expression could be observed; Nek2 protein was almost undetectable during G1 but accumulated progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that Nek2 resembles Aspergillus NIMA, not only in its catalytic domain, but also in its cell cycle-dependent expression. Hence, the human Nek2 protein kinase may also function at the onset of mitosis." @default.
• W1549553625 created "2016-06-24" @default.
• W1549553625 creator A5006574623 @default.
• W1549553625 creator A5025469280 @default.
• W1549553625 creator A5031392514 @default.
• W1549553625 creator A5055294285 @default.
• W1549553625 creator A5067286626 @default.
• W1549553625 date "1994-06-01" @default.
• W1549553625 modified "2023-09-25" @default.
• W1549553625 title "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans." @default.
• W1549553625 cites W1014698510 @default.
• W1549553625 cites W1523902693 @default.
• W1549553625 cites W1531747712 @default.
• W1549553625 cites W1542558659 @default.
• W1549553625 cites W1546570611 @default.
• W1549553625 cites W1594700207 @default.
• W1549553625 cites W1654164050 @default.
• W1549553625 cites W1773256867 @default.
• W1549553625 cites W1787382971 @default.
• W1549553625 cites W1872615920 @default.
• W1549553625 cites W1948489073 @default.
• W1549553625 cites W1954929088 @default.
• W1549553625 cites W1968144640 @default.
• W1549553625 cites W1982529170 @default.
• W1549553625 cites W1991101546 @default.
• W1549553625 cites W2004717166 @default.
• W1549553625 cites W2005038253 @default.
• W1549553625 cites W2006068720 @default.
• W1549553625 cites W2006543023 @default.
• W1549553625 cites W2020257412 @default.
• W1549553625 cites W2020946972 @default.
• W1549553625 cites W2024031273 @default.
• W1549553625 cites W2026777580 @default.
• W1549553625 cites W2029344014 @default.
• W1549553625 cites W2041082339 @default.
• W1549553625 cites W2074409447 @default.
• W1549553625 cites W2076241227 @default.
• W1549553625 cites W2078138394 @default.
• W1549553625 cites W2084404294 @default.
• W1549553625 cites W2088357331 @default.
• W1549553625 cites W2089414651 @default.
• W1549553625 cites W2093516457 @default.
• W1549553625 cites W2109436341 @default.
• W1549553625 cites W2128156628 @default.
• W1549553625 cites W2129350873 @default.
• W1549553625 cites W2132820021 @default.
• W1549553625 cites W2134812217 @default.
• W1549553625 cites W2137249911 @default.
• W1549553625 cites W2167737594 @default.
• W1549553625 cites W2227869250 @default.
• W1549553625 cites W2396727036 @default.
• W1549553625 cites W2471294740 @default.
• W1549553625 cites W316415966 @default.
• W1549553625 cites W564468169 @default.
• W1549553625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7522034" @default.
• W1549553625 hasPublicationYear "1994" @default.
• W1549553625 type Work @default.
• W1549553625 sameAs 1549553625 @default.
• W1549553625 citedByCount "42" @default.
• W1549553625 countsByYear W15495536252012 @default.
• W1549553625 countsByYear W15495536252013 @default.
• W1549553625 countsByYear W15495536252014 @default.
• W1549553625 countsByYear W15495536252015 @default.
• W1549553625 countsByYear W15495536252016 @default.
• W1549553625 countsByYear W15495536252017 @default.
• W1549553625 countsByYear W15495536252018 @default.
• W1549553625 countsByYear W15495536252020 @default.
• W1549553625 countsByYear W15495536252022 @default.
• W1549553625 crossrefType "journal-article" @default.
• W1549553625 hasAuthorship W1549553625A5006574623 @default.
• W1549553625 hasAuthorship W1549553625A5025469280 @default.
• W1549553625 hasAuthorship W1549553625A5031392514 @default.
• W1549553625 hasAuthorship W1549553625A5055294285 @default.
• W1549553625 hasAuthorship W1549553625A5067286626 @default.
• W1549553625 hasConcept C104317684 @default.
• W1549553625 hasConcept C143065580 @default.
• W1549553625 hasConcept C153911025 @default.
• W1549553625 hasConcept C184235292 @default.
• W1549553625 hasConcept C2776923806 @default.
• W1549553625 hasConcept C29537977 @default.
• W1549553625 hasConcept C54355233 @default.
• W1549553625 hasConcept C82495950 @default.
• W1549553625 hasConcept C84815855 @default.
• W1549553625 hasConcept C86803240 @default.
• W1549553625 hasConcept C93304396 @default.
• W1549553625 hasConcept C95444343 @default.
• W1549553625 hasConcept C97029542 @default.
• W1549553625 hasConceptScore W1549553625C104317684 @default.
• W1549553625 hasConceptScore W1549553625C143065580 @default.
• W1549553625 hasConceptScore W1549553625C153911025 @default.
• W1549553625 hasConceptScore W1549553625C184235292 @default.
• W1549553625 hasConceptScore W1549553625C2776923806 @default.
• W1549553625 hasConceptScore W1549553625C29537977 @default.
• W1549553625 hasConceptScore W1549553625C54355233 @default.
• W1549553625 hasConceptScore W1549553625C82495950 @default.
• W1549553625 hasConceptScore W1549553625C84815855 @default.
• W1549553625 hasConceptScore W1549553625C86803240 @default.
• W1549553625 hasConceptScore W1549553625C93304396 @default.

• next