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- W1549553708 abstract "This chapter reviews that the concept that the brain is a target for steroid hormones has abundant experimental support. Steroid hormones regulate the development and function of the nervous system, and affect mood, behavior, and cognition. Non-neuronal cells synthethize and metabolize steroid hormones, and produce local neuroactive steroids that exert neuromodulatory and neurotrophic actions under physiological and pathological conditions. In the central nervous system, the steroids produced by non-neuronal cells, such as pregnenolone, dehydroepiandrosterone (DHEA), testosterone, estradiol, progesterone, and other steroid metabolites, regulate synaptic function, affect anxiety, cognition, sleep and behavior, and exert neuroprotective and reparative roles. The chapter discusses that in the peripheral nervous system, progesterone and progesterone derivatives produced by Schwann cells, promote myelin formation, and the remyelination and regeneration of the injured nerves. Non-neuronal cells are also targets for steroids, and mediate or participate in many of the actions of these substances in the nervous system. These include: (2) the regulation of blood–brain barrier and cerebrovascular permeability by the actions of steroids on endothelial cells; (2) the regulation of synaptogenesis, synaptic plasticity, neuritic growth, and neuroendocrine secretion by the actions of steroids on astroglia, and (3) the regulation of neuronal survival and regeneration by the actions of steroids on microglia, astroglia, and Schwann cells." @default.
- W1549553708 created "2016-06-24" @default.
- W1549553708 creator A5002963265 @default.
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- W1549553708 creator A5083968750 @default.
- W1549553708 creator A5084187392 @default.
- W1549553708 creator A5086790573 @default.
- W1549553708 date "2003-01-01" @default.
- W1549553708 modified "2023-09-30" @default.
- W1549553708 title "Non-neuronal cells in the nervous system: sources and targets of neuroactive steroids" @default.
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