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- W1549581898 abstract "Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 μg) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-μg dose of anti-idiotope antibody induced the activation of a population of Thy 1.2+, Lyt 1−, 2+ suppressors. Both positive and negative regulatory activities were confined to the non-μ, idiotope+ compartment of the plaque-forming cell response. Administration of intermediate doses of anti-idiotope antibody resulted in an immune state indistinguishable from that of naive mice. This apparently normal response was in fact the product of a simultaneous activation of balanced enhancing and suppressive activities. When treated with anti-Lyt 2 or -Lyt 1 and complement, spleen cell populations taken from such phenotypically “naive” mice revealed latent idiotope-specific immunoenhancement or suppression, demonstrating the components of a functional regulatory equilibrium." @default.
- W1549581898 created "2016-06-24" @default.
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- W1549581898 date "1986-03-01" @default.
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- W1549581898 title "Regulation of the immune response" @default.
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- W1549581898 doi "https://doi.org/10.1016/0008-8749(86)90275-3" @default.
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