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• W1549634535 abstract "ABSTRACT Primary cutaneous γδ‐T‐cell lymphoma (CGD‐TCL) is a rare entity of cutaneous T‐cell lymphomas (CTCL) and is characterized by tumoral growth of mature γδ‐T‐cell expressing cytotoxic molecules. The prognosis of CGD‐TCL is generally worse than other CTCL. However, relatively indolent patch/plaque lesions have been described suggesting the heterogeneous nature of this entity. Here, we present a case of CGD‐TCL with various skin manifestations, such as erythematous plaques/tumors and subcutaneous panniculitis‐like lesions. During the follow up, testicular involvement was detected, which was surgically removed. Histopathology showed mixed features from epidermotropism, dermal infiltration and subcutaneous panniculitis‐like lesions depending on the clinical manifestations. The tumor cells were positive for CD3 and revealed cytotoxic markers, TIA‐1 and perforin, but not for CD4, CD8, CD20, CD56, TCRβF1 or EBER. Topical glucocorticoid ointment, narrowband ultraviolet B (NB‐UVB) irradiation and low‐dose methotrexate (MTX) were effective to control these skin lesions. No visceral involvement was detected thereafter. While CGD‐TCL is usually associated with poor prognosis, it seems to be composed of various clinical manifestations, and NB‐UVB and low‐dose MTX could be a choice for indolent patch/plaque and possibly nodular lesions, especially for the aged." @default.
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• W1549634535 date "2010-09-28" @default.
• W1549634535 modified "2023-10-16" @default.
• W1549634535 title "Primary cutaneous γδ-T-cell lymphoma treated with low-dose methotrexate and narrowband ultraviolet B irradiation: Report of a case with testicular involvement" @default.
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• W1549634535 doi "https://doi.org/10.1111/j.1346-8138.2010.00998.x" @default.
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