FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549634562> ?p ?o ?g. }

• W1549634562 endingPage "8917" @default.
• W1549634562 startingPage "8912" @default.
• W1549634562 abstract "We have previously shown that a mutant human insulin receptor with a COOH-terminal 43-amino acid deletion (HIR delta CT), when expressed in Rat 1 fibroblasts, binds insulin normally, autophosphorylates, and undergoes endocytosis after insulin binding in a manner comparable to the normal human insulin receptor (HIRc). In this paper we have examined the biologic activity of the truncated and normal insulin receptors. In vitro, the HIR delta CT receptors caused a 1.8-fold greater phosphorylation of a Glu4/Tyr1 polypeptide than did the HIRc receptors, but the two receptor types were nearly equivalent in their ability to phosphorylate a src-derived peptide. Furthermore, insulin preactivation of HIRc and HIR delta CT receptors in intact cells led to equivalent stimulation of tyrosine kinase activity as subsequently determined for histone in vitro. Expression of HIRc receptors in cells led to enhanced sensitivity to insulin of 2-deoxy-D-glucose uptake and glycogen synthase activation. This increased sensitivity was proportional to receptor number at low (Ro = 6400) but not at high (Ro = 1.25 X 10(6] levels of receptor expression. However, expression of HIR delta CT receptors (Ro = 2.5 X 10(5] led to little, if any, increase in insulin sensitivity of either 2-deoxy-D-glucose uptake or glycogen synthase activation. Furthermore, compared with HIRc cells, HIR delta CT cells respond poorly to an agonistic monoclonal antibody specific for the human insulin receptor. In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro. Despite this, however, the receptor displays low activity in mediating the metabolic effects of insulin." @default.
• W1549634562 created "2016-06-24" @default.
• W1549634562 creator A5025252627 @default.
• W1549634562 creator A5031406465 @default.
• W1549634562 creator A5036033738 @default.
• W1549634562 creator A5038461976 @default.
• W1549634562 creator A5063103432 @default.
• W1549634562 creator A5064952661 @default.
• W1549634562 creator A5087133747 @default.
• W1549634562 creator A5090328045 @default.
• W1549634562 creator A5091832115 @default.
• W1549634562 date "1988-06-01" @default.
• W1549634562 modified "2023-10-14" @default.
• W1549634562 title "Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects." @default.
• W1549634562 cites W1505075493 @default.
• W1549634562 cites W1529786888 @default.
• W1549634562 cites W1533778697 @default.
• W1549634562 cites W1570426544 @default.
• W1549634562 cites W1971972894 @default.
• W1549634562 cites W1980137209 @default.
• W1549634562 cites W1991710558 @default.
• W1549634562 cites W1995337883 @default.
• W1549634562 cites W1996544551 @default.
• W1549634562 cites W1997732080 @default.
• W1549634562 cites W2001866120 @default.
• W1549634562 cites W2016910304 @default.
• W1549634562 cites W2030156849 @default.
• W1549634562 cites W2068118253 @default.
• W1549634562 cites W2074871218 @default.
• W1549634562 cites W2122567567 @default.
• W1549634562 cites W2149731942 @default.
• W1549634562 cites W2176848385 @default.
• W1549634562 cites W2306142335 @default.
• W1549634562 doi "https://doi.org/10.1016/s0021-9258(18)68394-2" @default.
• W1549634562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2837468" @default.
• W1549634562 hasPublicationYear "1988" @default.
• W1549634562 type Work @default.
• W1549634562 sameAs 1549634562 @default.
• W1549634562 citedByCount "130" @default.
• W1549634562 countsByYear W15496345622015 @default.
• W1549634562 countsByYear W15496345622016 @default.
• W1549634562 crossrefType "journal-article" @default.
• W1549634562 hasAuthorship W1549634562A5025252627 @default.
• W1549634562 hasAuthorship W1549634562A5031406465 @default.
• W1549634562 hasAuthorship W1549634562A5036033738 @default.
• W1549634562 hasAuthorship W1549634562A5038461976 @default.
• W1549634562 hasAuthorship W1549634562A5063103432 @default.
• W1549634562 hasAuthorship W1549634562A5064952661 @default.
• W1549634562 hasAuthorship W1549634562A5087133747 @default.
• W1549634562 hasAuthorship W1549634562A5090328045 @default.
• W1549634562 hasAuthorship W1549634562A5091832115 @default.
• W1549634562 hasBestOaLocation W15496345621 @default.
• W1549634562 hasConcept C106195933 @default.
• W1549634562 hasConcept C112446052 @default.
• W1549634562 hasConcept C119857082 @default.
• W1549634562 hasConcept C134018914 @default.
• W1549634562 hasConcept C170493617 @default.
• W1549634562 hasConcept C185592680 @default.
• W1549634562 hasConcept C2777391703 @default.
• W1549634562 hasConcept C2779306644 @default.
• W1549634562 hasConcept C2779664074 @default.
• W1549634562 hasConcept C41008148 @default.
• W1549634562 hasConcept C55493867 @default.
• W1549634562 hasConcept C62478195 @default.
• W1549634562 hasConcept C76155785 @default.
• W1549634562 hasConcept C86803240 @default.
• W1549634562 hasConcept C95444343 @default.
• W1549634562 hasConceptScore W1549634562C106195933 @default.
• W1549634562 hasConceptScore W1549634562C112446052 @default.
• W1549634562 hasConceptScore W1549634562C119857082 @default.
• W1549634562 hasConceptScore W1549634562C134018914 @default.
• W1549634562 hasConceptScore W1549634562C170493617 @default.
• W1549634562 hasConceptScore W1549634562C185592680 @default.
• W1549634562 hasConceptScore W1549634562C2777391703 @default.
• W1549634562 hasConceptScore W1549634562C2779306644 @default.
• W1549634562 hasConceptScore W1549634562C2779664074 @default.
• W1549634562 hasConceptScore W1549634562C41008148 @default.
• W1549634562 hasConceptScore W1549634562C55493867 @default.
• W1549634562 hasConceptScore W1549634562C62478195 @default.
• W1549634562 hasConceptScore W1549634562C76155785 @default.
• W1549634562 hasConceptScore W1549634562C86803240 @default.
• W1549634562 hasConceptScore W1549634562C95444343 @default.
• W1549634562 hasIssue "18" @default.
• W1549634562 hasLocation W15496345621 @default.
• W1549634562 hasOpenAccess W1549634562 @default.
• W1549634562 hasPrimaryLocation W15496345621 @default.
• W1549634562 hasRelatedWork W1983641721 @default.
• W1549634562 hasRelatedWork W2043964728 @default.
• W1549634562 hasRelatedWork W2062216595 @default.
• W1549634562 hasRelatedWork W2098842401 @default.
• W1549634562 hasRelatedWork W2109607186 @default.
• W1549634562 hasRelatedWork W2122944464 @default.
• W1549634562 hasRelatedWork W2135403984 @default.
• W1549634562 hasRelatedWork W2148162837 @default.
• W1549634562 hasRelatedWork W2150233632 @default.
• W1549634562 hasRelatedWork W2435813906 @default.
• W1549634562 hasVolume "263" @default.
• W1549634562 isParatext "false" @default.

• next