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- W1549698085 abstract "Secondary metabolites ranging from furanone to exo-polysaccharides have been suggested to have anti-biofilm activity in various recent studies. Among these,Escherichia coli group II capsular polysaccharides were shown to inhibit biofilm formation in a wide range of organisms and more recently marine Vibrio sp. and Kingella kingae were found to secrete complex exopolysaccharides having the potential for broad-spectrum biofilm inhibition and disruption.In this study, a ca. 1800 kDA polysaccharide having simple monomeric units of α-Dgalactopyranosyl-(1→2)-glycerol-phosphate was found to exert an anti-biofilm activityagainst both Gram-positive and Gram-negative bacteria without any bactericidal effect.This polysaccharide was extracted from a Bacillus licheniformis strain associated with the Mediterranean marine organism Spongia officinalis. Unlike most of the anti-biofilm compounds, the mechanism of action of the compound was most likely independent from quorum sensing, as its structure is unrelated to any of the so far known quorum sensing molecules. This was unexpected, since previous studies had shown that the combined action of α-D-galactopyranosyl-glycerol (floridoside) and isethionic acid (floridosideisethionic acid complex) from red algae had anti-biofilm effect through quorum sensing inhibition.Other experiments revealed that treatment of abiotic surfaces with the present polysaccharide blocked and/or reduced the initial adhesion and biofilm development ofstrains such as Escherichia coli PHL628 and Pseudomonas fluorescens. In addition the polysaccharide reduced the cell surface hydrophobicity of the tested strains whichappeared to be a cause of reduction of cell-cell or cell-surface interaction during the initial attachment stage of biofilm development.Further research on such surface-active compounds might help in developing novel and more potential anti-biofilm molecules." @default.
- W1549698085 created "2016-06-24" @default.
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- W1549698085 date "2011-11-24" @default.
- W1549698085 modified "2023-09-23" @default.
- W1549698085 title "Anti-biofilm activity of a polysaccharide from marine spongeassociated Bacillus licheniformis" @default.
- W1549698085 doi "https://doi.org/10.6092/unina/fedoa/8546" @default.
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