Matches in SemOpenAlex for { <https://semopenalex.org/work/W1549851488> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1549851488 endingPage "519" @default.
- W1549851488 startingPage "509" @default.
- W1549851488 abstract "Rates of H+ secretion and transepithelial resistance were measured for gastric mucosas from neonatal piglets before and after the addition of histamine and with the deployment of conditions that inhibit HCl secretion. At designated times tissue biopsy specimens were taken and prepared for electron microscopy. Oxyntic cell morphology was evaluated by classification of the cells into one of four categories: resting, partially stimulated, stimulated, or returning. Morphologic profiles for each experimental condition were thus established. In order to assess this method of quantitation, detailed morphometric analyses of oxyntic cells from resting and stimulated preparations were undertaken. The observed differences in tubulovesicular and microvillar surface densities were similar to those of previous investigators and correlated well with the morphologic profiles for these conditions. Actively secreting gastric preparations subjected to 15 mM NaSCN, substrate deprivation, or removal of histamine showed an inhibition of HCl secretion coupled with an increase in tissue resistance. However, only the morphologic profile of cells from the latter condition was different from that observed for control stimulated cells; histamine removal caused cells to be predominantly of a resting or returning morphology. Treatment of resting tissue with SCN- or removal of substrate inhibited subsequent histamine-induced secretion though tissue resistance decreased somewhat (approximately 15%). The morphologic profile of cells from these conditions was similar to that of control stimulated cells, despite the lack of acid secretion. These data support the hypothesis that oxyntic cell morphology does not absolutely dictate the secretory state of the tissue and that the resistance of gastric mucosa cannot be accounted for solely by the ultrastructure (i.e., surface area) of oxyntic cells." @default.
- W1549851488 created "2016-06-24" @default.
- W1549851488 creator A5026523722 @default.
- W1549851488 creator A5057502768 @default.
- W1549851488 creator A5062720676 @default.
- W1549851488 date "1981-09-01" @default.
- W1549851488 modified "2023-10-14" @default.
- W1549851488 title "Inhibition of HCl secretion and the effects on ultrastructure and electrical resistance in isolated piglet gastric mucosa" @default.
- W1549851488 cites W1985401588 @default.
- W1549851488 cites W1989741587 @default.
- W1549851488 cites W2040223798 @default.
- W1549851488 cites W2078453162 @default.
- W1549851488 cites W2085181720 @default.
- W1549851488 cites W2159342124 @default.
- W1549851488 cites W2255204984 @default.
- W1549851488 cites W2396170225 @default.
- W1549851488 cites W2412334117 @default.
- W1549851488 cites W2427446381 @default.
- W1549851488 cites W2434339444 @default.
- W1549851488 cites W316285066 @default.
- W1549851488 cites W4296284118 @default.
- W1549851488 cites W4300476926 @default.
- W1549851488 doi "https://doi.org/10.1016/0016-5085(81)90603-x" @default.
- W1549851488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7250638" @default.
- W1549851488 hasPublicationYear "1981" @default.
- W1549851488 type Work @default.
- W1549851488 sameAs 1549851488 @default.
- W1549851488 citedByCount "40" @default.
- W1549851488 countsByYear W15498514882012 @default.
- W1549851488 countsByYear W15498514882018 @default.
- W1549851488 crossrefType "journal-article" @default.
- W1549851488 hasAuthorship W1549851488A5026523722 @default.
- W1549851488 hasAuthorship W1549851488A5057502768 @default.
- W1549851488 hasAuthorship W1549851488A5062720676 @default.
- W1549851488 hasBestOaLocation W15498514881 @default.
- W1549851488 hasConcept C105702510 @default.
- W1549851488 hasConcept C1122143 @default.
- W1549851488 hasConcept C126322002 @default.
- W1549851488 hasConcept C134018914 @default.
- W1549851488 hasConcept C1491633281 @default.
- W1549851488 hasConcept C186199130 @default.
- W1549851488 hasConcept C2777504413 @default.
- W1549851488 hasConcept C2779422922 @default.
- W1549851488 hasConcept C2781443798 @default.
- W1549851488 hasConcept C49039625 @default.
- W1549851488 hasConcept C55493867 @default.
- W1549851488 hasConcept C71924100 @default.
- W1549851488 hasConcept C86803240 @default.
- W1549851488 hasConcept C87555872 @default.
- W1549851488 hasConceptScore W1549851488C105702510 @default.
- W1549851488 hasConceptScore W1549851488C1122143 @default.
- W1549851488 hasConceptScore W1549851488C126322002 @default.
- W1549851488 hasConceptScore W1549851488C134018914 @default.
- W1549851488 hasConceptScore W1549851488C1491633281 @default.
- W1549851488 hasConceptScore W1549851488C186199130 @default.
- W1549851488 hasConceptScore W1549851488C2777504413 @default.
- W1549851488 hasConceptScore W1549851488C2779422922 @default.
- W1549851488 hasConceptScore W1549851488C2781443798 @default.
- W1549851488 hasConceptScore W1549851488C49039625 @default.
- W1549851488 hasConceptScore W1549851488C55493867 @default.
- W1549851488 hasConceptScore W1549851488C71924100 @default.
- W1549851488 hasConceptScore W1549851488C86803240 @default.
- W1549851488 hasConceptScore W1549851488C87555872 @default.
- W1549851488 hasIssue "3" @default.
- W1549851488 hasLocation W15498514881 @default.
- W1549851488 hasLocation W15498514882 @default.
- W1549851488 hasOpenAccess W1549851488 @default.
- W1549851488 hasPrimaryLocation W15498514881 @default.
- W1549851488 hasRelatedWork W1967922938 @default.
- W1549851488 hasRelatedWork W2031810107 @default.
- W1549851488 hasRelatedWork W2071721110 @default.
- W1549851488 hasRelatedWork W2150451493 @default.
- W1549851488 hasRelatedWork W2326784413 @default.
- W1549851488 hasRelatedWork W2367755553 @default.
- W1549851488 hasRelatedWork W2433741083 @default.
- W1549851488 hasRelatedWork W26842269 @default.
- W1549851488 hasRelatedWork W357902070 @default.
- W1549851488 hasRelatedWork W4205738382 @default.
- W1549851488 hasVolume "81" @default.
- W1549851488 isParatext "false" @default.
- W1549851488 isRetracted "false" @default.
- W1549851488 magId "1549851488" @default.
- W1549851488 workType "article" @default.