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- W1549867133 abstract "Over the last four decades, cardiac transplantation has become the preferred therapy for select patients with end-stage heart disease. Improvements in immunosuppression, donor procurement, surgical techniques, and post-transplant care have resulted in a substantial improvement in Drug-Drug interactions may have potentially life-threatening consequences in transplant recipients' survival. Nonetheless, problems still exist and the purpose of this chapter is to provide an overview of long-term complications of heart transplantation in the current era. This chapter reviews the major causes of mortality (rejection, infection, malignancy, transplant coronary artery disease) and morbidity (renal dysfunction, hypertension, diabetes, dyslipidemia, osteoporosis and gout) after transplantation. While current therapies are focused on preventing and treating rejection, limiting long-term problems of cardiac allograft vasculopathy, and malignancy, future advances in monitoring assays will allow better assessment of rejection and the level of immune response. This will enable clinicians to tailor current therapies to the needs of individual heart transplant recipients to maximize benefit and minimize toxicity." @default.
- W1549867133 created "2016-06-24" @default.
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- W1549867133 date "2014-07-25" @default.
- W1549867133 modified "2023-09-25" @default.
- W1549867133 title "Long‐term Outcomes after Heart Transplantation" @default.
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- W1549867133 doi "https://doi.org/10.1002/9781118873434.ch105" @default.
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