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- W155004254 abstract "BackgroundHistorically, alkylator-based therapy has been used to treat patients with chronic lymphocytic leukemia (CLL). More effective therapies, such as the use of monoclonal antibodies in combination with chemotherapy, have been shown to prolong both progression-free survival and overall survival. Improvements in the identification of prognostic markers for CLL, as well as novel combinations for chemoimmunotherapy regimens, have improved the outcome for patients with CLL.MethodsWe examine the diagnosis of CLL, the role of prognostic factors in determining treatment goals, and current data on frontline management of CLL.ResultsThe benefits of single-agent and combination therapies are associated with prolonged progression-free and overall survival. While more aggressive management may therefore be warranted, each patient's comorbidities and performance status must be weighed against the benefits, availability, cost, treatment goals, and incidence of adverse effects associated with each therapy.ConclusionsNew single agents and novel treatment combinations have shown promising results in phase I/II studies. The ultimate therapeutic goals of prolonged survival and improved quality of life will be validated only by ongoing clinical and laboratory research and by continuous enrollment of patients in clinical trials." @default.
- W155004254 created "2016-06-24" @default.
- W155004254 creator A5006298674 @default.
- W155004254 creator A5060360947 @default.
- W155004254 date "2012-01-01" @default.
- W155004254 modified "2023-09-23" @default.
- W155004254 title "Front-Line Therapy for Chronic Lymphocytic Leukemia" @default.
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- W155004254 doi "https://doi.org/10.1177/107327481201900104" @default.
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