Matches in SemOpenAlex for { <https://semopenalex.org/work/W1550113143> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1550113143 endingPage "137" @default.
- W1550113143 startingPage "129" @default.
- W1550113143 abstract "To overproduce erythromycin C, B or D and evaluate the effect of disruption of tailoring genes eryK and eryG in an industrial erythromycin producer. The tailoring genes eryG and eryK were inactivated individually or simultaneously by targeted gene disruption in an industrial strain Saccharopolyspora erythraea HL3168 E3, resulting in the overproduction of erythromycin C (2·48 g l(-1) ), B (1·70 g l(-1) ) or D (2·15 g l(-1) ) in the mutant strain QL-G, QL-K or QL-KG, respectively. Analysis of the erythromycin congeners throughout the fermentation indicated that, at the end of fermentation, comparatively large amount of erythromycin D (0·67 g l(-1) ) was accumulated in QL-G, whereas only small amount of erythromycin D (0·10 g l(-1) ) was produced in QL-K.Inactivation of tailoring genes eryG and eryK in the high producer did not affect the biosynthesis of erythromycin. However, erythromycin D could be more efficiently methylated by EryG than be hydroxylated by EryK.Development of the mutant strains provides a method for the economical large-scale production of potent lead compounds. The information about the accumulation and conversion of erythromycins in the industrial strains may contribute to further improving erythromycin production." @default.
- W1550113143 created "2016-06-24" @default.
- W1550113143 creator A5005242519 @default.
- W1550113143 creator A5018676940 @default.
- W1550113143 creator A5047170240 @default.
- W1550113143 creator A5060634768 @default.
- W1550113143 creator A5060818313 @default.
- W1550113143 creator A5067419825 @default.
- W1550113143 creator A5083090692 @default.
- W1550113143 date "2010-12-22" @default.
- W1550113143 modified "2023-09-27" @default.
- W1550113143 title "Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios" @default.
- W1550113143 cites W1554154724 @default.
- W1550113143 cites W169459663 @default.
- W1550113143 cites W1891331951 @default.
- W1550113143 cites W1963833742 @default.
- W1550113143 cites W1971788559 @default.
- W1550113143 cites W1974112253 @default.
- W1550113143 cites W1975690561 @default.
- W1550113143 cites W1995995599 @default.
- W1550113143 cites W2005617334 @default.
- W1550113143 cites W2015715032 @default.
- W1550113143 cites W2028020780 @default.
- W1550113143 cites W2028114445 @default.
- W1550113143 cites W2046564154 @default.
- W1550113143 cites W2047489087 @default.
- W1550113143 cites W2048619259 @default.
- W1550113143 cites W2057821939 @default.
- W1550113143 cites W2063362030 @default.
- W1550113143 cites W2064375265 @default.
- W1550113143 cites W2073932577 @default.
- W1550113143 cites W2101039289 @default.
- W1550113143 cites W2132732379 @default.
- W1550113143 cites W2142933316 @default.
- W1550113143 cites W2170290078 @default.
- W1550113143 doi "https://doi.org/10.1111/j.1472-765x.2010.02973.x" @default.
- W1550113143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21175699" @default.
- W1550113143 hasPublicationYear "2010" @default.
- W1550113143 type Work @default.
- W1550113143 sameAs 1550113143 @default.
- W1550113143 citedByCount "4" @default.
- W1550113143 countsByYear W15501131432013 @default.
- W1550113143 countsByYear W15501131432016 @default.
- W1550113143 countsByYear W15501131432019 @default.
- W1550113143 crossrefType "journal-article" @default.
- W1550113143 hasAuthorship W1550113143A5005242519 @default.
- W1550113143 hasAuthorship W1550113143A5018676940 @default.
- W1550113143 hasAuthorship W1550113143A5047170240 @default.
- W1550113143 hasAuthorship W1550113143A5060634768 @default.
- W1550113143 hasAuthorship W1550113143A5060818313 @default.
- W1550113143 hasAuthorship W1550113143A5067419825 @default.
- W1550113143 hasAuthorship W1550113143A5083090692 @default.
- W1550113143 hasBestOaLocation W15501131431 @default.
- W1550113143 hasConcept C100544194 @default.
- W1550113143 hasConcept C104317684 @default.
- W1550113143 hasConcept C105702510 @default.
- W1550113143 hasConcept C124420848 @default.
- W1550113143 hasConcept C143065580 @default.
- W1550113143 hasConcept C185592680 @default.
- W1550113143 hasConcept C2778022156 @default.
- W1550113143 hasConcept C2780206985 @default.
- W1550113143 hasConcept C501593827 @default.
- W1550113143 hasConcept C55493867 @default.
- W1550113143 hasConcept C86803240 @default.
- W1550113143 hasConcept C89423630 @default.
- W1550113143 hasConceptScore W1550113143C100544194 @default.
- W1550113143 hasConceptScore W1550113143C104317684 @default.
- W1550113143 hasConceptScore W1550113143C105702510 @default.
- W1550113143 hasConceptScore W1550113143C124420848 @default.
- W1550113143 hasConceptScore W1550113143C143065580 @default.
- W1550113143 hasConceptScore W1550113143C185592680 @default.
- W1550113143 hasConceptScore W1550113143C2778022156 @default.
- W1550113143 hasConceptScore W1550113143C2780206985 @default.
- W1550113143 hasConceptScore W1550113143C501593827 @default.
- W1550113143 hasConceptScore W1550113143C55493867 @default.
- W1550113143 hasConceptScore W1550113143C86803240 @default.
- W1550113143 hasConceptScore W1550113143C89423630 @default.
- W1550113143 hasIssue "2" @default.
- W1550113143 hasLocation W15501131431 @default.
- W1550113143 hasLocation W15501131432 @default.
- W1550113143 hasOpenAccess W1550113143 @default.
- W1550113143 hasPrimaryLocation W15501131431 @default.
- W1550113143 hasRelatedWork W1978748382 @default.
- W1550113143 hasRelatedWork W2021612150 @default.
- W1550113143 hasRelatedWork W2049069172 @default.
- W1550113143 hasRelatedWork W2063907463 @default.
- W1550113143 hasRelatedWork W2347818856 @default.
- W1550113143 hasRelatedWork W2364235101 @default.
- W1550113143 hasRelatedWork W2371091493 @default.
- W1550113143 hasRelatedWork W2403412381 @default.
- W1550113143 hasRelatedWork W2772654151 @default.
- W1550113143 hasRelatedWork W217093250 @default.
- W1550113143 hasVolume "52" @default.
- W1550113143 isParatext "false" @default.
- W1550113143 isRetracted "false" @default.
- W1550113143 magId "1550113143" @default.
- W1550113143 workType "article" @default.