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- W1550117175 abstract "Initial management of patients with thyroid cancer often includes total thyroidectomy, long-term treatment with L-thyroxine often at doses sufficient for suppression of pituitary production of thyrotropin (TSH), and eradication of iodine-avid tissue (benign or malignant) with radioactive iodine in selected cases. Residual thyroid cancer will be present, or disease will recur, in ~ 15–20 % of patients, thereby leading to recommendations for long-term monitoring. In addition to careful interval patient history and physical examination, measurement of circulating levels of thyroglobulin and radiographic imaging are employed. Measurement of serum thyroglobulin, functional imaging with radioiodine, and structural imaging are used to monitor thyroid cancer patients. Of these, thyroglobulin measurement and radioiodine scans are relatively thyroid specific, providing high degrees of specificity. However, the sensitivities of iodine scanning and, in some cases, thyroglobulin measurement are limited by the small relative amount of thyroid tissue present in patients treated by thyroidectomy and dedifferentiation of tumor cells compared to normal thyrocytes. Therefore, radioiodine imaging and therapy require stimulation of thyroid tissue by elevated levels of TSH, and thyroglobulin measurement is also enhanced by TSH stimulation." @default.
- W1550117175 created "2016-06-24" @default.
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- W1550117175 date "2016-01-01" @default.
- W1550117175 modified "2023-09-25" @default.
- W1550117175 title "Recombinant Human Thyrotropin" @default.
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- W1550117175 doi "https://doi.org/10.1007/978-1-4939-3314-3_10" @default.
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