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• W1550119609 abstract "Genetic factors play a substantial role in susceptibility to common diseases such as type 2 diabetes (T2DM) and obesity-related disorders. The current investigation was undertaken to examine the association of genetic variants that indirectly affect diabetesrelated traits through their effects on birth weight and adiposity in South Asian Indians. Additionally, the thesis was extended to examine the plausibility of differences in body composition in Asian Indians, compared to the West, as a contributing factor to premature cardio-metabolic risk in Indians. The first study investigated the association of two birth-weight lowering genetic variants in the ADCY5 and near CCNL1 locus with birth weight and adult glycemic traits. Although the significant associations between both genetic variants and birth weight as observed in Western cohorts were not seen, the ADCY5 variant displayed an association with increased glucose and decreased fasting insulin response, which supports the fetal-insulin hypothesis proposing a common genetic factor linking birth weight and adult T2DM traits. Recent GWAS have shown that associations of certain variants with birth weight is secondary to their effects on adiposity, and the strong link between obesity and T2DM stimulated further examination of the effect of genetic variants on obesity and diabetes-related traits. In Paper II, it was confirmed that the common FTO variant exerts an effect on obesity traits in adult Indians similar to that in Caucasians. A subsequent investigation (Paper III) of the effects of FTO and MC4R in adolescents (mean ± SD age, 17.1 ±1.9 years) demonstrated an association with waisthip ratio, providing evidence that the preferential accumulation of central fat in Indians isregulated by FTO in younger age groups. This could be a constitutional Asian Indian effect, and underpins the importance of ethnic-specific differences in fat distribution. These FTO associations with obesity and T2DM traits in adults were further strengthened by a meta-analysis of ~23,000 Asian Indians (Paper IV), in which a consistent obesity-related effect was observed, in addition to an effect on T2DM which seemed to be partially mediated through body mass index (BMI). The strong association of FTO with waist circumference and subcutaneous adipose tissue (SAT) proxies led to an investigation of the differences in abdominal adiposity depots in Indians compared to Caucasians, using dual energy X-ray absorptiometry (DXA) as described in Paper V. Compared with a BMI-, gender- and age-matched Western cohort, Asian Indians exhibited relatively less visceral fat accumulation and more subcutaneous fat, reinforcing that ethnic differences in fat distribution need to be appreciated when analyzing the connection between obesity and T2DM. In conclusion, the effect of ADCY5 on glucose regulation confirms that impaired glucose homeostasis in adulthood is related to birth weight mediated through mechanisms that involve fetal-insulin signaling. Regarding genetic effects on adiposity, the effect estimate of the FTO locus on obesity and diabetes-related traits in Asian Indians is similar to that in Western ethnicities. The relative absence of differences in visceral adiposity, and a predominance of subcutaneous fat accumulation along with lower muscle mass and higher overall body fat in Asian Indians, provides novel insights to investigate the role of specific adipose depots and skeletal muscle in relation to heightened cardio-metabolic risk in this population." @default.
• W1550119609 created "2016-06-24" @default.
• W1550119609 creator A5075387129 @default.
• W1550119609 date "2013-08-12" @default.
• W1550119609 modified "2023-09-24" @default.
• W1550119609 title "Genetic epidemiology of adiposity and abnormal glucose tolerance in South Asian Indians" @default.
• W1550119609 cites W106630790 @default.
• W1550119609 cites W121579194 @default.
• W1550119609 cites W1522239197 @default.
• W1550119609 cites W1527649416 @default.
• W1550119609 cites W1531334610 @default.
• W1550119609 cites W1551600243 @default.
• W1550119609 cites W1552620713 @default.
• W1550119609 cites W1579199574 @default.
• W1550119609 cites W1583605376 @default.
• W1550119609 cites W1629867331 @default.
• W1550119609 cites W1690786713 @default.
• W1550119609 cites W1878893076 @default.
• W1550119609 cites W1880851560 @default.
• W1550119609 cites W1893179590 @default.
• W1550119609 cites W1900468389 @default.
• W1550119609 cites W1912145057 @default.
• W1550119609 cites W1927710737 @default.
• W1550119609 cites W1932533342 @default.
• W1550119609 cites W1937192900 @default.
• W1550119609 cites W1944558458 @default.
• W1550119609 cites W1950253279 @default.
• W1550119609 cites W1960454382 @default.
• W1550119609 cites W1963689297 @default.
• W1550119609 cites W1963983596 @default.
• W1550119609 cites W1964871265 @default.
• W1550119609 cites W1965141016 @default.
• W1550119609 cites W1965581424 @default.
• W1550119609 cites W1965842672 @default.
• W1550119609 cites W1966311394 @default.
• W1550119609 cites W1968215122 @default.
• W1550119609 cites W1969060340 @default.
• W1550119609 cites W1969235931 @default.
• W1550119609 cites W1969384718 @default.
• W1550119609 cites W1969673534 @default.
• W1550119609 cites W1970232115 @default.
• W1550119609 cites W1974073207 @default.
• W1550119609 cites W1974256272 @default.
• W1550119609 cites W1976210931 @default.
• W1550119609 cites W1977390310 @default.
• W1550119609 cites W1978215768 @default.
• W1550119609 cites W1979338372 @default.
• W1550119609 cites W1980248069 @default.
• W1550119609 cites W1980991473 @default.
• W1550119609 cites W1981025527 @default.
• W1550119609 cites W1982074303 @default.
• W1550119609 cites W1984623971 @default.
• W1550119609 cites W1986055989 @default.
• W1550119609 cites W1987493079 @default.
• W1550119609 cites W1988286232 @default.
• W1550119609 cites W1989020172 @default.
• W1550119609 cites W1991265507 @default.
• W1550119609 cites W1998657633 @default.
• W1550119609 cites W2001368367 @default.
• W1550119609 cites W2001913879 @default.
• W1550119609 cites W2002186226 @default.
• W1550119609 cites W2002654539 @default.
• W1550119609 cites W2002699471 @default.
• W1550119609 cites W2002848248 @default.
• W1550119609 cites W2004299376 @default.
• W1550119609 cites W2005428158 @default.
• W1550119609 cites W2005701363 @default.
• W1550119609 cites W2006704526 @default.
• W1550119609 cites W2007078899 @default.
• W1550119609 cites W2008679996 @default.
• W1550119609 cites W2011470760 @default.
• W1550119609 cites W2012037560 @default.
• W1550119609 cites W2012367206 @default.
• W1550119609 cites W2013317847 @default.
• W1550119609 cites W2016679723 @default.
• W1550119609 cites W2019276898 @default.
• W1550119609 cites W2022671594 @default.
• W1550119609 cites W2025143098 @default.
• W1550119609 cites W2025590766 @default.
• W1550119609 cites W2026367730 @default.
• W1550119609 cites W2027934956 @default.
• W1550119609 cites W2028335133 @default.
• W1550119609 cites W2028920300 @default.
• W1550119609 cites W2030670140 @default.
• W1550119609 cites W2031235005 @default.
• W1550119609 cites W2032383912 @default.
• W1550119609 cites W2032530751 @default.
• W1550119609 cites W2033585778 @default.
• W1550119609 cites W2036168461 @default.
• W1550119609 cites W2036329920 @default.
• W1550119609 cites W2037519948 @default.
• W1550119609 cites W2038142353 @default.
• W1550119609 cites W2038961236 @default.
• W1550119609 cites W2041467022 @default.
• W1550119609 cites W2043176891 @default.
• W1550119609 cites W2044958038 @default.
• W1550119609 cites W2044981034 @default.
• W1550119609 cites W2045841831 @default.
• W1550119609 cites W2046562263 @default.
• W1550119609 cites W2046920899 @default.

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