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- W1550132324 abstract "Irradiated (NZB×BALB/c)F1 mice were injected with syngeneic bone marrow cells, syngeneic or parental thymus cells, and sheep red cells. The antibody plaque-forming cell response depended on the number of sheep cells and the age and strain of the thymus cells. Young or adult BALB/c thymus, and young hybrid thymus, responded best to low numbers of sheep cells; with higher numbers they became tolerant. Adult hybrid thymus, and young or adult NZB thymus, responded better to high numbers of sheep cells. Hybrid mice irradiated and restored with BALB/c bone marrow developed thymus cells with the reactivity of BALB/c thymus. It is argued that NZB mice, and older hybrids, may develop autoimmunity because of an abnormality of tolerance induction manifested in their thymus cells, but of bone marrow origin." @default.
- W1550132324 created "2016-06-24" @default.
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- W1550132324 date "1971-12-01" @default.
- W1550132324 modified "2023-10-18" @default.
- W1550132324 title "Strain differences in the immune responses of mice. 3. A raised tolerance threshold in NZB thymus cells." @default.
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