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- W1550146624 abstract "Objective To observe the dynamic expression of TGF-β1 and pathological features of the livers of BALB/c mice infected with Echinococcus multilocularis(Em).Methods Sixty BALB/c mice were randomly divided into 2 groups,an experimental group and a control group.Em infection was performed after laparotomy by intra-hepatic injection of a metacestode suspension(experimental animals) or of a medium used to prepare the metacestode suspension(control animals) under a surgical microscope.After 2 days,8 days,4 weeks,12 weeks,24 weeks and 36 weeks,samples of mouse liver were collected and subjected to HE and Masson staining.The dynamic changes in liver TGF-β1 expression in BALB/c mice infected with Em was analyzed immuno-histochemically.Results At different times during the course of Em infection,pathological changes were observed in the liver of the experimental group,including inflammatory cell invasion,steatosis,necrosis,calcification,and the formation of cyst walls.The level of TGF-β1 expression increased as the hepatic tissue morphology changed to hepatocytic stroma.In the experimental group,the expression of TGF-β1 was positive in(1.44±3.22)%(4 weeks),(18.83±4.03)%(12 weeks),(9.44±4.71)%(24 weeks),and(8.13±3.65)%(36 weeks);in the control group,this expression was positive in(2.43±1.91)%(24 weeks) and(0.29±0.65)%(36 weeks).There was a significant difference between the experimental group and the control group at 12 weeks and 36 weeks(P0.05).Conclusion TGF-β1 expression in the liver of mice infected with Em increased and remained high during Em infection and may have been involved in the pathogenesis and development of liver fibrosis." @default.
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- W1550146624 date "2009-01-01" @default.
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- W1550146624 title "Dynamic changes in liver TGF-β1 expression in BALB/c mice infected with Echinococcus multilocularis." @default.
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