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- W1550168118 abstract "Quantitative (Population-) Epigenetics describes the variability observed in characters due to factors in the environment induced primarily by the gamut of chemical compounds screened for regulatory efficacy. Likewise, index selection based on the statistical Quantitative (Population-) Epigenetics theory can be used to improve efficiency in screening compounds for their potential to enhance quantitative characters such as yield, stability and resistance to unfavourable environmental influences (e.g., water stress, cold temperatures or disease resistance). Optimal screening efficiency of regulator-active compounds is obtained with high environmental variability, low heritability (characters for which the genotype sets a wide ‘norm of reaction’ on environmental influences), high correlation between characters under indirect selection and intensity of selection is shown. Keywords: Biologically-active chemical compounds, efficacy value, environmental variation, genetic analogues, genotype, heritability, index selection, phenotype, quantitative characters, screening efficiency Quantitative Populations-Epigenetik beim Screening und der Entwicklung von regulatorisch aktiven Substanzen Quantitative (Populations-) Epigenetik beschreibt die durch regulatorische Substanzen als Umweltfaktoren bewirkte Variabilitat von Merkmalen. Die Anwendung von Indexselektion auf Grundlage der statistischen Quantitativen (Populations-) Epigenetik-Theorie zur Erhohung der Screeningeffizienz von chemischen Substanzen bei quantitativen landwirtschaftlichen Merkmalen wie zum Beispiel Ertrag, Standfestigkeit oder Erhohung der Widerstandsfahigkeit gegen negative Umweltfaktoren (z. B. Wassermangel, Frost oder Krankheiten), wird dargestellt. Optimale Screeningeffizienz bei regulatorisch wirksamen Substanzen wird erzielt bei groser Umweltvariabilitat, bei niedriger Heritabilitat (Merkmale, bei denen der Genotyp eine grose Reaktionsbreite (‘norm of reaction’) fur die Modifikation durch die Umwelt zulasst), bei hoher Korrelation zwischen Hilfsmerkmal und Zielmerkmal bei indirekter Selektion und mit hoher Selektionsintensitat. Stichworter: Biologisch aktive chemische Substanzen, genetische Analogie, Genotyp, Heritabilitat, Phanotyp, quantitative Merkmale, Screeningeffizienz, umweltbedingte Variabilitat, Wirkungswert" @default.
- W1550168118 created "2016-06-24" @default.
- W1550168118 creator A5012191642 @default.
- W1550168118 date "2012-03-13" @default.
- W1550168118 modified "2023-09-24" @default.
- W1550168118 title "Quantitative population-epigenetics in screening and development of regulator-active compounds" @default.
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- W1550168118 doi "https://doi.org/10.5073/jka.2012.434.074" @default.
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