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• W1550194328 abstract "Life is a dynamic process, which depends upon the interaction among inanimate molecules. Living organisms have the capacity to utilize external energy and matter to maintain and propagate them. The interactions between substrate and enzyme that account for the catalysis and specificity of the reactions of intermediary metabolism also account for the energy-coupling processes, which enable the exchange of chemical energy and allow the system to do work. Because of their relative masses, the electron density distribution controls the movement of nuclei. Electronic interactions and distortions of electron density distributions are responsible not only for the formation of structures and complexes but also for chemical reactions themselves. The chapter examines the forces that hold enzymes in their unique three-dimensional structure, then the energetics of enzyme–substrate interactions and finally, the forces or mechanism by which the bond-making and -breaking processes occur during the reaction catalyzed by the enzyme." @default.
• W1550194328 created "2016-06-24" @default.
• W1550194328 creator A5062098859 @default.
• W1550194328 date "1984-01-01" @default.
• W1550194328 modified "2023-10-03" @default.
• W1550194328 title "Chapter 1 The energetics and specificity of enzyme—substrate interactions" @default.
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• W1550194328 doi "https://doi.org/10.1016/s0167-7306(08)60372-5" @default.
• W1550194328 hasPublicationYear "1984" @default.
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