Matches in SemOpenAlex for { <https://semopenalex.org/work/W1550198541> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1550198541 endingPage "182" @default.
- W1550198541 startingPage "175" @default.
- W1550198541 abstract "1. In organ cultures of mammary tissue from C3H mice we observed increases in the activity of glucose 6-phosphate dehydrogenase similar to that occurring at parturition. 2. In 22hr. cultures of tissue from late-pregnant mice insulin was required for the increases, but the further addition of prolactin, corticosterone and certain other hormones had no effect. The rise in activity occurred over the second half of the culture period. 3. Results from culture of adipose tissue, and mammary tissue rich in adipose tissue, strongly suggest that the rise in activity occurs in mammary parenchymal rather than adipose cells. 4. In 45hr. cultures prolactin prevented a fall in enzyme activity between 22hr. and 45hr. If the medium contained serum the activity at 22hr. was unaffected, but it continued to rise up to 45hr., and prolactin then had no effect. 5. The enzyme also increased in activity in cultures of mammary tissue from mid-pregnant mice. Insulin was again required, the activity was higher at 45hr. than at 24hr. and prolactin increased the activities at both these times. 6. Actinomycin D, cycloheximide and puromycin at low concentration in the media of 22hr. cultures all prevented increases in enzyme activity. Hydroxyurea at a concentration that inhibited the incorporation of [3H]thymidine into DNA by 92% had little effect. 7. Actinomycin D and cycloheximide largely failed to prevent the rise in enzyme activity if added after 3·5hr. and 12hr. respectively. Hence all essential RNA and protein synthesis appears to be finished by 3·5hr. and 12hr., although most of the increase in enzyme activity occurs gradually between 12hr. and 22hr. 8. We suggest that the increases in enzyme activity, both in culture and in the living animal at parturition, are induced by an influx of glucose that is restrained during pregnancy by the growth-hormone-like action of placental lactogen." @default.
- W1550198541 created "2016-06-24" @default.
- W1550198541 creator A5009896011 @default.
- W1550198541 creator A5042353978 @default.
- W1550198541 date "1969-06-01" @default.
- W1550198541 modified "2023-09-26" @default.
- W1550198541 title "Increase in activity of glucose 6-phosphate dehydrogenase in mouse mammary tissue cultured with insulin" @default.
- W1550198541 cites W12169015 @default.
- W1550198541 cites W1500064513 @default.
- W1550198541 cites W1503262957 @default.
- W1550198541 cites W1716826009 @default.
- W1550198541 cites W1906197854 @default.
- W1550198541 cites W1978254320 @default.
- W1550198541 cites W2000705479 @default.
- W1550198541 cites W2009882028 @default.
- W1550198541 cites W2012221604 @default.
- W1550198541 cites W2021619301 @default.
- W1550198541 cites W2022207894 @default.
- W1550198541 cites W2044163321 @default.
- W1550198541 cites W2061148492 @default.
- W1550198541 cites W2067559652 @default.
- W1550198541 cites W2074754198 @default.
- W1550198541 cites W2321999068 @default.
- W1550198541 cites W2332033889 @default.
- W1550198541 cites W2396131453 @default.
- W1550198541 cites W2400460144 @default.
- W1550198541 cites W2413412002 @default.
- W1550198541 cites W81152036 @default.
- W1550198541 doi "https://doi.org/10.1042/bj1130175" @default.
- W1550198541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1184617" @default.
- W1550198541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5806389" @default.
- W1550198541 hasPublicationYear "1969" @default.
- W1550198541 type Work @default.
- W1550198541 sameAs 1550198541 @default.
- W1550198541 citedByCount "28" @default.
- W1550198541 crossrefType "journal-article" @default.
- W1550198541 hasAuthorship W1550198541A5009896011 @default.
- W1550198541 hasAuthorship W1550198541A5042353978 @default.
- W1550198541 hasBestOaLocation W15501985412 @default.
- W1550198541 hasConcept C126322002 @default.
- W1550198541 hasConcept C134018914 @default.
- W1550198541 hasConcept C171089720 @default.
- W1550198541 hasConcept C181199279 @default.
- W1550198541 hasConcept C202751555 @default.
- W1550198541 hasConcept C2778128677 @default.
- W1550198541 hasConcept C2779064019 @default.
- W1550198541 hasConcept C2779200571 @default.
- W1550198541 hasConcept C2779306644 @default.
- W1550198541 hasConcept C28212737 @default.
- W1550198541 hasConcept C3675279 @default.
- W1550198541 hasConcept C552990157 @default.
- W1550198541 hasConcept C55493867 @default.
- W1550198541 hasConcept C64241487 @default.
- W1550198541 hasConcept C71315377 @default.
- W1550198541 hasConcept C71924100 @default.
- W1550198541 hasConcept C86803240 @default.
- W1550198541 hasConcept C90703135 @default.
- W1550198541 hasConceptScore W1550198541C126322002 @default.
- W1550198541 hasConceptScore W1550198541C134018914 @default.
- W1550198541 hasConceptScore W1550198541C171089720 @default.
- W1550198541 hasConceptScore W1550198541C181199279 @default.
- W1550198541 hasConceptScore W1550198541C202751555 @default.
- W1550198541 hasConceptScore W1550198541C2778128677 @default.
- W1550198541 hasConceptScore W1550198541C2779064019 @default.
- W1550198541 hasConceptScore W1550198541C2779200571 @default.
- W1550198541 hasConceptScore W1550198541C2779306644 @default.
- W1550198541 hasConceptScore W1550198541C28212737 @default.
- W1550198541 hasConceptScore W1550198541C3675279 @default.
- W1550198541 hasConceptScore W1550198541C552990157 @default.
- W1550198541 hasConceptScore W1550198541C55493867 @default.
- W1550198541 hasConceptScore W1550198541C64241487 @default.
- W1550198541 hasConceptScore W1550198541C71315377 @default.
- W1550198541 hasConceptScore W1550198541C71924100 @default.
- W1550198541 hasConceptScore W1550198541C86803240 @default.
- W1550198541 hasConceptScore W1550198541C90703135 @default.
- W1550198541 hasIssue "1" @default.
- W1550198541 hasLocation W15501985411 @default.
- W1550198541 hasLocation W15501985412 @default.
- W1550198541 hasLocation W15501985413 @default.
- W1550198541 hasLocation W15501985414 @default.
- W1550198541 hasOpenAccess W1550198541 @default.
- W1550198541 hasPrimaryLocation W15501985411 @default.
- W1550198541 hasRelatedWork W1523349002 @default.
- W1550198541 hasRelatedWork W1957106181 @default.
- W1550198541 hasRelatedWork W2002232110 @default.
- W1550198541 hasRelatedWork W2012310860 @default.
- W1550198541 hasRelatedWork W2044897248 @default.
- W1550198541 hasRelatedWork W2056633665 @default.
- W1550198541 hasRelatedWork W2081564223 @default.
- W1550198541 hasRelatedWork W2092927280 @default.
- W1550198541 hasRelatedWork W2159949415 @default.
- W1550198541 hasRelatedWork W2167414261 @default.
- W1550198541 hasVolume "113" @default.
- W1550198541 isParatext "false" @default.
- W1550198541 isRetracted "false" @default.
- W1550198541 magId "1550198541" @default.
- W1550198541 workType "article" @default.