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• W1550331214 abstract "Basically, two types of approaches are currently being developed for tooth engineering. The first one consists in the engineering of dental constituents, such as the periodontium, the pulp/dentin, or the enamel/dentin complexes (Duan et al., 2011; Honda et al., 2009; Huang, 2009; Park et al., 2010). In parallel with these experiments of tissue engineering, attempts are also made to reconstruct a whole tooth (Arany et al., 2009; Honda et al., 2008; Hu et al., 2006a; Komine et al., 2007; Nakao et al., 2007; Ohazama et al., 2004). Most of this chapter will consider the second goal, and only use data from tooth tissue engineering, when they bring information about the cellular or molecular mechanisms that are involved and/or about the specific constraints, which they may illustrate. Few groups are interested in a biomimetic approach to engineer a whole tooth, including crown, roots, and periodontium by using cultured cell-cell re-associations and trying to recapitulate the successive steps of tooth development (Arany et al., 2009; Honda et al., 2008; Hu et al., 2006a; Nakao et al., 2007; Ohazama et al., 2004). Specific questions arising from this research concern the experimental design, and the search for easily available cell sources. The panel of approaches is progressively restricted by two types of biological constraints: those specifically related to tooth functionality and those related to more general biological aspects such as the maintenance of the cell heterogeneity in the dental mesenchyme and in the periodontium, keeping the gradients of cell differentiation and their 3D-geometry, or the maintenance of the cell kinetic parameters to ensure the differential cusp timing and growth. These complementary points will be discussed in light of parallel approaches being developed by different groups." @default.
• W1550331214 created "2016-06-24" @default.
• W1550331214 creator A5009462531 @default.
• W1550331214 creator A5009908050 @default.
• W1550331214 creator A5033020273 @default.
• W1550331214 creator A5081224847 @default.
• W1550331214 date "2011-08-17" @default.
• W1550331214 modified "2023-09-23" @default.
• W1550331214 title "Tooth Organ Engineering: Biological Constraints Specifying Experimental Approaches" @default.
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