FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1550446171> ?p ?o ?g. }

• W1550446171 abstract "The filarial parasite, Dirofilaria immitis, infects dogs and canids in warm and tropical areas of the globe. Located in the right pulmonary arteries, the heartworm infection is a severe and potentially fatal disease; caused mainly by the adult worm stages. The zoonotic roundworm is transmitted by various mosquitoes, Culicidae. Currently, control measures are based on monthly prophylaxis with macrocyclic lactones (MLs). The only adulticide treatment is melarsomine dihydrochloride injected intramuscularly which can cause complications. Resistance is emerging against the MLs, increasing the necessity to find novel anthelmintics. The recently discovered class of anthelmintics, amino acetonitriles derivatives (AADs), with a new mode of action brought hope in the battle against helminth parasites. The aim of this thesis was to find candidate targets of AADs and other potential anthelmintics in D. immitis genome that could be used as therapeutic targets. The first chapter discusses the possible mechanisms of antiparasitic drug action and selectivity. The second chapter tests and confirms the efficacy of AADs against D. immitis in vitro. This suggests the presence of receptor(s) to AADs in the heartworm, a hypothesis which can be tested by genome sequencing.The third chapter narrates the story of the genome project of the heartworm; de novo sequenced with Illumina HiSeq and assembled with Abyss and Velvet. This did not indicate that there is an AAD receptor (DEG-3-subfamily), to Caenorhabditis elegans and Haemonchus contortus in D. immitis genome. In fact, D. immitis does not appear to possess a single gene of the DEG-3 subfamily of acetylcholine receptors, the targets of monepantel. However, in-depth studies of the genome through exclusion criteria established a list of novel potential drug targets.The fourth chapter further investigates the presumed loss of the DEG-3-subfamily in D. immitis and relates this finding to the sensitivity against both monepantel enantiomers in vitro and in vivo.The fifth chapter picks up some of the newly identified candidate drug targets. It tests the predicted targets against the heartworm with known inhibitors.This thesis presents a genomic approach to identify potential targets and new anthelmintics. I hope that, the genomic approach will support the development of drugs against the heartworm and related parasites." @default.
• W1550446171 created "2016-06-24" @default.
• W1550446171 creator A5062385064 @default.
• W1550446171 date "2012-01-01" @default.
• W1550446171 modified "2023-09-27" @default.
• W1550446171 title "Drug targets of the heartworm, Dirofilaria immitis" @default.
• W1550446171 cites W1423657362 @default.
• W1550446171 cites W1507315541 @default.
• W1550446171 cites W1550209048 @default.
• W1550446171 cites W155395694 @default.
• W1550446171 cites W1580596049 @default.
• W1550446171 cites W1658221551 @default.
• W1550446171 cites W1840915262 @default.
• W1550446171 cites W1892897526 @default.
• W1550446171 cites W1927652072 @default.
• W1550446171 cites W1966822396 @default.
• W1550446171 cites W1969457013 @default.
• W1550446171 cites W1974646727 @default.
• W1550446171 cites W1977118166 @default.
• W1550446171 cites W1980133202 @default.
• W1550446171 cites W1980751766 @default.
• W1550446171 cites W1986892223 @default.
• W1550446171 cites W1988676851 @default.
• W1550446171 cites W1988929438 @default.
• W1550446171 cites W1991253147 @default.
• W1550446171 cites W1992595091 @default.
• W1550446171 cites W1994327660 @default.
• W1550446171 cites W2001801485 @default.
• W1550446171 cites W2002861734 @default.
• W1550446171 cites W2002875415 @default.
• W1550446171 cites W2009526805 @default.
• W1550446171 cites W2010124676 @default.
• W1550446171 cites W2014420927 @default.
• W1550446171 cites W2019122328 @default.
• W1550446171 cites W2020608708 @default.
• W1550446171 cites W2023025638 @default.
• W1550446171 cites W2031874486 @default.
• W1550446171 cites W2036615634 @default.
• W1550446171 cites W2041902449 @default.
• W1550446171 cites W2048474231 @default.
• W1550446171 cites W2051039710 @default.
• W1550446171 cites W2055043387 @default.
• W1550446171 cites W2056621266 @default.
• W1550446171 cites W2061656750 @default.
• W1550446171 cites W2062162317 @default.
• W1550446171 cites W2062670236 @default.
• W1550446171 cites W2064913142 @default.
• W1550446171 cites W2065213545 @default.
• W1550446171 cites W2065599864 @default.
• W1550446171 cites W2066368686 @default.
• W1550446171 cites W2067360806 @default.
• W1550446171 cites W2075560011 @default.
• W1550446171 cites W2075836195 @default.
• W1550446171 cites W2077784761 @default.
• W1550446171 cites W2083854815 @default.
• W1550446171 cites W2084459566 @default.
• W1550446171 cites W2085683495 @default.
• W1550446171 cites W2092784580 @default.
• W1550446171 cites W2093603395 @default.
• W1550446171 cites W2093615671 @default.
• W1550446171 cites W2093873814 @default.
• W1550446171 cites W2098207011 @default.
• W1550446171 cites W2103154918 @default.
• W1550446171 cites W2103566634 @default.
• W1550446171 cites W2103903744 @default.
• W1550446171 cites W2106882534 @default.
• W1550446171 cites W2107847732 @default.
• W1550446171 cites W2109974623 @default.
• W1550446171 cites W2112446373 @default.
• W1550446171 cites W2114611642 @default.
• W1550446171 cites W2115726385 @default.
• W1550446171 cites W2117936709 @default.
• W1550446171 cites W2123668698 @default.
• W1550446171 cites W2127230663 @default.
• W1550446171 cites W2128114769 @default.
• W1550446171 cites W2131071295 @default.
• W1550446171 cites W2134800079 @default.
• W1550446171 cites W2137597742 @default.
• W1550446171 cites W2138270253 @default.
• W1550446171 cites W2139062153 @default.
• W1550446171 cites W2140053876 @default.
• W1550446171 cites W2140698423 @default.
• W1550446171 cites W2141885858 @default.
• W1550446171 cites W2144008452 @default.
• W1550446171 cites W2145278357 @default.
• W1550446171 cites W2159946869 @default.
• W1550446171 cites W2160265043 @default.
• W1550446171 cites W2162010421 @default.
• W1550446171 cites W2166612397 @default.
• W1550446171 cites W2167260302 @default.
• W1550446171 cites W2168909179 @default.
• W1550446171 cites W2170946319 @default.
• W1550446171 cites W2171158206 @default.
• W1550446171 cites W2181381358 @default.
• W1550446171 cites W2182057602 @default.
• W1550446171 cites W2182766361 @default.
• W1550446171 cites W2414771395 @default.
• W1550446171 cites W2490312691 @default.
• W1550446171 cites W2561442667 @default.
• W1550446171 cites W2952615746 @default.

• next