FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1550720904> ?p ?o ?g. }

• W1550720904 abstract "In this study we test the hypothesis that immortalized adult rat Sertoli cells respond to known testicular toxins in a similar manner to Sertoli cells tested in vivo and in primary culture. This cell line was developed by immortalizing adult rat Sertoli cells with the temperature-sensitive mutant of SV40, ts255, such that the cells proliferate at the permissive temperature of 33 degrees C but express differentiated characteristics at the nonpermissive temperature of 40 degrees C. Confluent monolayers, grown at 33 degrees C or 40 degrees C, were exposed to a range of concentrations of dinitrobenzene (DNB) or dinitrotoluene (DNT) isomers or to cadmium chloride. Cellular response was assessed by neutral-red cell viability assay and ultrastructural changes. Cells grown at 40 degrees C were sensitive to lower concentrations of each toxicant than were cells grown at 33 degrees C. 1,2-DNB was more toxic than 1,3-DNB, and 3,4-DNT was more toxic than 2,4-DNT, as judged by the neutral-red cell viability assay. Ultrastructurally, cells treated with 1,2-DNB or 2,4-DNT showed increased numbers of autophagic vesicles compared to controls. Intercellular penetration of ruthenium red demonstrated breached tight junctions in 1,2-DNB and cadmium-treated cells. From these observations, we conclude that this cell line can serve as a model for studying toxic mechanisms in adult Sertoli cells." @default.
• W1550720904 created "2016-06-24" @default.
• W1550720904 creator A5030579186 @default.
• W1550720904 creator A5077102408 @default.
• W1550720904 date "2003-01-01" @default.
• W1550720904 modified "2023-09-23" @default.
• W1550720904 cites W1543329883 @default.
• W1550720904 cites W1767407931 @default.
• W1550720904 cites W189576857 @default.
• W1550720904 cites W193893899 @default.
• W1550720904 cites W1968691118 @default.
• W1550720904 cites W1977977327 @default.
• W1550720904 cites W1978258769 @default.
• W1550720904 cites W1979429407 @default.
• W1550720904 cites W1989764974 @default.
• W1550720904 cites W1990956809 @default.
• W1550720904 cites W1994061862 @default.
• W1550720904 cites W1997656957 @default.
• W1550720904 cites W1998188254 @default.
• W1550720904 cites W1998722329 @default.
• W1550720904 cites W2006688676 @default.
• W1550720904 cites W2012337697 @default.
• W1550720904 cites W2031503260 @default.
• W1550720904 cites W2051632482 @default.
• W1550720904 cites W2062761624 @default.
• W1550720904 cites W2062819604 @default.
• W1550720904 cites W2071934356 @default.
• W1550720904 cites W2083344555 @default.
• W1550720904 cites W2084616540 @default.
• W1550720904 cites W2088686339 @default.
• W1550720904 cites W2094297139 @default.
• W1550720904 cites W2104427497 @default.
• W1550720904 cites W2132638453 @default.
• W1550720904 cites W2133166914 @default.
• W1550720904 cites W2157380583 @default.
• W1550720904 cites W2159625360 @default.
• W1550720904 cites W2270220644 @default.
• W1550720904 cites W2399541278 @default.
• W1550720904 cites W2409059022 @default.
• W1550720904 doi "https://doi.org/10.1023/a:1023359222963" @default.
• W1550720904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12776928" @default.
• W1550720904 hasPublicationYear "2003" @default.
• W1550720904 type Work @default.
• W1550720904 sameAs 1550720904 @default.
• W1550720904 citedByCount "6" @default.
• W1550720904 countsByYear W15507209042013 @default.
• W1550720904 countsByYear W15507209042016 @default.
• W1550720904 crossrefType "journal-article" @default.
• W1550720904 hasAuthorship W1550720904A5030579186 @default.
• W1550720904 hasAuthorship W1550720904A5077102408 @default.
• W1550720904 hasBestOaLocation W15507209042 @default.
• W1550720904 hasConcept C109316439 @default.
• W1550720904 hasConcept C123765429 @default.
• W1550720904 hasConcept C12554922 @default.
• W1550720904 hasConcept C134018914 @default.
• W1550720904 hasConcept C153911025 @default.
• W1550720904 hasConcept C16685009 @default.
• W1550720904 hasConcept C178790620 @default.
• W1550720904 hasConcept C185592680 @default.
• W1550720904 hasConcept C202751555 @default.
• W1550720904 hasConcept C2777366897 @default.
• W1550720904 hasConcept C2778643788 @default.
• W1550720904 hasConcept C2780473477 @default.
• W1550720904 hasConcept C2780484033 @default.
• W1550720904 hasConcept C2781068068 @default.
• W1550720904 hasConcept C29730261 @default.
• W1550720904 hasConcept C53227056 @default.
• W1550720904 hasConcept C54355233 @default.
• W1550720904 hasConcept C544657597 @default.
• W1550720904 hasConcept C55493867 @default.
• W1550720904 hasConcept C71924100 @default.
• W1550720904 hasConcept C79879829 @default.
• W1550720904 hasConcept C81885089 @default.
• W1550720904 hasConcept C86803240 @default.
• W1550720904 hasConcept C95444343 @default.
• W1550720904 hasConceptScore W1550720904C109316439 @default.
• W1550720904 hasConceptScore W1550720904C123765429 @default.
• W1550720904 hasConceptScore W1550720904C12554922 @default.
• W1550720904 hasConceptScore W1550720904C134018914 @default.
• W1550720904 hasConceptScore W1550720904C153911025 @default.
• W1550720904 hasConceptScore W1550720904C16685009 @default.
• W1550720904 hasConceptScore W1550720904C178790620 @default.
• W1550720904 hasConceptScore W1550720904C185592680 @default.
• W1550720904 hasConceptScore W1550720904C202751555 @default.
• W1550720904 hasConceptScore W1550720904C2777366897 @default.
• W1550720904 hasConceptScore W1550720904C2778643788 @default.
• W1550720904 hasConceptScore W1550720904C2780473477 @default.
• W1550720904 hasConceptScore W1550720904C2780484033 @default.
• W1550720904 hasConceptScore W1550720904C2781068068 @default.
• W1550720904 hasConceptScore W1550720904C29730261 @default.
• W1550720904 hasConceptScore W1550720904C53227056 @default.
• W1550720904 hasConceptScore W1550720904C54355233 @default.
• W1550720904 hasConceptScore W1550720904C544657597 @default.
• W1550720904 hasConceptScore W1550720904C55493867 @default.
• W1550720904 hasConceptScore W1550720904C71924100 @default.
• W1550720904 hasConceptScore W1550720904C79879829 @default.
• W1550720904 hasConceptScore W1550720904C81885089 @default.
• W1550720904 hasConceptScore W1550720904C86803240 @default.
• W1550720904 hasConceptScore W1550720904C95444343 @default.
• W1550720904 hasLocation W15507209041 @default.

• next