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• W155081372 abstract "The present series of studies of CSF monoamine metabolites support the hypothesis of a role for serotonin in depressive illness, insofar that depressed patients have slightly lower CSF 5-HIAA concentrations than normal controls. Apparently a normal association between CSF 5-HIAA and platelet MAO activity is disrupted in depression. The importance of serotonin does not, however, appear to be confined to depressive illness. There is a strong association between a low CSF 5-HIAA and a tendency to suicidal behaviour, also outside the setting of depression. The nature of this relationship is unclear, but it is suggested that certain personality features may form a mediating link. A connection between a low serotonin turnover and a weakened control of aggressive or hostile impulses is one possibility." @default.
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• W155081372 date "1981-01-01" @default.
• W155081372 modified "2023-09-26" @default.
• W155081372 title "Studies of CSF 5-HIAA in Depression and Suicidal Behaviour" @default.
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• W155081372 doi "https://doi.org/10.1007/978-1-4684-3860-4_41" @default.
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