Matches in SemOpenAlex for { <https://semopenalex.org/work/W1550872554> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1550872554 abstract "Objective: We aimed to determine therapeutic effects of novel oral anticoagulants (NOACs) on cardiac thrombi in acute stroke. Methods: We studied consecutive acute ischemic stroke/TIA patients with non-valvular atrial fibrillation who started to take rivaroxaban or dabigatran and was diagnosed as having cardiac thrombi on transesophageal echocardiography (TEE) within 10 days after the admission between July 2012 and July 2013. All continued to take NOACs without additional antithrombotic agents. Plasma concentrations for rivaroxaban were calibrated based on anti-Xa chromogenic assay for rivaroxaban (Stago®) and thrombin clotting time assay for dabigatran (Hemoclot®) just before (trough) and 4h after medication (peak) at steady state. Results: Eight patients (7 men, 52-83 years old) were studied. Their BW ranged 41.0-88.8 kg, CHADS2 ranged 2-5, and NIHSS ranged 2-18. NOACs were initiated at median 3 days and TEE was performed at median 3 days after admission. As a NOAC, one patient took 15 mg o. d. of rivaroxaban, 5 took 10 mg o.d. of rivaroxaban (officially approved dose in Japan) and the other 2 took 110 mg b.i.d. of dabigatran. For all the patients, the thrombus was identified in the left atrial appendage with median size of 14.7 mm; two of them were hyperechoic, being judged as already-organized. In follow-up TEE examinations median 19 days after admission , 5 thrombi disappeared (rivaroxaban in 3, dabigatran in 2), 1 diminished in size (rivaroxaban), and the other 2, all being initially hyperechoic, did not change (rivaroxaban for both). For 6 patients with absolute/partial dissolution of the thrombi, median peak/trough concentrations of rivaroxaban were 69 (19-255)/10 (range10-20) ng/ml, and those of dabigatran were 100 (40-160)/40 (20-60) ng/ml, median peak/trough aPTT was 42/34.5 s in rivaroxaban users and 45/37 s in dabigatran users, and median peak/trough PT was 20.2/12.9 s and 15.3/13.3 s, respectively. Conclusion: Rivaroxaban and dabigatran have potential to resolve non-organized cardiac thrombi. Monotherapy using NOACs may be enough for early prevention of recurrent stroke in patients with cardioembolic stroke/TIA." @default.
- W1550872554 created "2016-06-24" @default.
- W1550872554 creator A5015658424 @default.
- W1550872554 creator A5018515174 @default.
- W1550872554 creator A5024000275 @default.
- W1550872554 creator A5030240622 @default.
- W1550872554 creator A5035717519 @default.
- W1550872554 creator A5042534277 @default.
- W1550872554 creator A5055860707 @default.
- W1550872554 creator A5076132169 @default.
- W1550872554 date "2014-02-01" @default.
- W1550872554 modified "2023-09-26" @default.
- W1550872554 title "Abstract T P348: Successful Resolution of the Cardiac Thrombus Using Novel Oral Anticoagulants" @default.
- W1550872554 doi "https://doi.org/10.1161/str.45.suppl_1.tp348" @default.
- W1550872554 hasPublicationYear "2014" @default.
- W1550872554 type Work @default.
- W1550872554 sameAs 1550872554 @default.
- W1550872554 citedByCount "0" @default.
- W1550872554 crossrefType "journal-article" @default.
- W1550872554 hasAuthorship W1550872554A5015658424 @default.
- W1550872554 hasAuthorship W1550872554A5018515174 @default.
- W1550872554 hasAuthorship W1550872554A5024000275 @default.
- W1550872554 hasAuthorship W1550872554A5030240622 @default.
- W1550872554 hasAuthorship W1550872554A5035717519 @default.
- W1550872554 hasAuthorship W1550872554A5042534277 @default.
- W1550872554 hasAuthorship W1550872554A5055860707 @default.
- W1550872554 hasAuthorship W1550872554A5076132169 @default.
- W1550872554 hasConcept C126322002 @default.
- W1550872554 hasConcept C127413603 @default.
- W1550872554 hasConcept C164705383 @default.
- W1550872554 hasConcept C2776301958 @default.
- W1550872554 hasConcept C2778661090 @default.
- W1550872554 hasConcept C2778810321 @default.
- W1550872554 hasConcept C2779161974 @default.
- W1550872554 hasConcept C2780645631 @default.
- W1550872554 hasConcept C2781362458 @default.
- W1550872554 hasConcept C42219234 @default.
- W1550872554 hasConcept C71924100 @default.
- W1550872554 hasConcept C78519656 @default.
- W1550872554 hasConceptScore W1550872554C126322002 @default.
- W1550872554 hasConceptScore W1550872554C127413603 @default.
- W1550872554 hasConceptScore W1550872554C164705383 @default.
- W1550872554 hasConceptScore W1550872554C2776301958 @default.
- W1550872554 hasConceptScore W1550872554C2778661090 @default.
- W1550872554 hasConceptScore W1550872554C2778810321 @default.
- W1550872554 hasConceptScore W1550872554C2779161974 @default.
- W1550872554 hasConceptScore W1550872554C2780645631 @default.
- W1550872554 hasConceptScore W1550872554C2781362458 @default.
- W1550872554 hasConceptScore W1550872554C42219234 @default.
- W1550872554 hasConceptScore W1550872554C71924100 @default.
- W1550872554 hasConceptScore W1550872554C78519656 @default.
- W1550872554 hasLocation W15508725541 @default.
- W1550872554 hasOpenAccess W1550872554 @default.
- W1550872554 hasPrimaryLocation W15508725541 @default.
- W1550872554 hasRelatedWork W1963394471 @default.
- W1550872554 hasRelatedWork W2125957676 @default.
- W1550872554 hasRelatedWork W2128943756 @default.
- W1550872554 hasRelatedWork W2355421283 @default.
- W1550872554 hasRelatedWork W2658888906 @default.
- W1550872554 hasRelatedWork W2765176336 @default.
- W1550872554 hasRelatedWork W2887051952 @default.
- W1550872554 hasRelatedWork W2893221462 @default.
- W1550872554 hasRelatedWork W2893679522 @default.
- W1550872554 hasRelatedWork W2967885760 @default.
- W1550872554 hasRelatedWork W2975416619 @default.
- W1550872554 hasRelatedWork W3002512199 @default.
- W1550872554 hasRelatedWork W3011329159 @default.
- W1550872554 hasRelatedWork W3030120190 @default.
- W1550872554 hasRelatedWork W3031393417 @default.
- W1550872554 hasRelatedWork W3031904935 @default.
- W1550872554 hasRelatedWork W3032197895 @default.
- W1550872554 hasRelatedWork W3049615954 @default.
- W1550872554 hasRelatedWork W3157729190 @default.
- W1550872554 hasRelatedWork W3176673472 @default.
- W1550872554 isParatext "false" @default.
- W1550872554 isRetracted "false" @default.
- W1550872554 magId "1550872554" @default.
- W1550872554 workType "article" @default.